Ontology type: schema:Chapter
1987
AUTHORSH. Mabuchi , N. Kamon , H. Fujita , I. Michishita , M. Takeda , K. Kajinami , H. Itoh , T. Wakasugi , R. Takeda
ABSTRACTFamilial hypercholesterolemia is an autosomal dominant disorder characterized by elevated levels of low-density lipoprotein (LDL) cholesterol, tendon xanthomas, and premature coronary artery disease (CAD) (1). The disorder results from a complete or partial defect of the LDL receptor (1) that normally controls the degradation of LDL. Reduction of LDL-cholesterol levels has proved to be effective in decreasing the incidence of CAD (2, 3). Compactin (4) and mevinolin (5), competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, are effective in lowering cholesterol levels of patients with familial hypercholesterolemia. These drugs lower plasma LDL by decreasing the rate of LDL production and stimulating the production of LDL receptor in the liver (6) (Fig. 1). LDL receptor has a specific binding activity for apolipoproteins B and E (7). The apolipoprotein B is present in very low-density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and LDL (8), which are highly associated with CAD (9, 10). Apolipoproteins A-I and A-II are primary apolipo-proteins in high-density lipoprotein (HDL) (8), and apolipoprotein A-I in patients with CAD has been demonstrated to be decreased (11). More... »
PAGES260-268
Drugs Affecting Lipid Metabolism
ISBN
978-3-642-71704-8
978-3-642-71702-4
http://scigraph.springernature.com/pub.10.1007/978-3-642-71702-4_49
DOIhttp://dx.doi.org/10.1007/978-3-642-71702-4_49
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1051880374
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1101",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical Biochemistry and Metabolomics",
"type": "DefinedTerm"
}
],
"author": [
{
"familyName": "Mabuchi",
"givenName": "H.",
"id": "sg:person.01154062341.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154062341.76"
],
"type": "Person"
},
{
"familyName": "Kamon",
"givenName": "N.",
"id": "sg:person.01013672342.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013672342.45"
],
"type": "Person"
},
{
"familyName": "Fujita",
"givenName": "H.",
"id": "sg:person.0711142437.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711142437.68"
],
"type": "Person"
},
{
"familyName": "Michishita",
"givenName": "I.",
"id": "sg:person.0732262025.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732262025.70"
],
"type": "Person"
},
{
"familyName": "Takeda",
"givenName": "M.",
"id": "sg:person.0670213705.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670213705.97"
],
"type": "Person"
},
{
"familyName": "Kajinami",
"givenName": "K.",
"id": "sg:person.01017622015.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017622015.68"
],
"type": "Person"
},
{
"familyName": "Itoh",
"givenName": "H.",
"id": "sg:person.016647555142.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016647555142.20"
],
"type": "Person"
},
{
"familyName": "Wakasugi",
"givenName": "T.",
"id": "sg:person.0623417033.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623417033.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Second Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan",
"id": "http://www.grid.ac/institutes/grid.9707.9",
"name": [
"The Second Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan"
],
"type": "Organization"
},
"familyName": "Takeda",
"givenName": "R.",
"id": "sg:person.01340001663.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340001663.38"
],
"type": "Person"
}
],
"datePublished": "1987",
"datePublishedReg": "1987-01-01",
"description": "Familial hypercholesterolemia is an autosomal dominant disorder characterized by elevated levels of low-density lipoprotein (LDL) cholesterol, tendon xanthomas, and premature coronary artery disease (CAD) (1). The disorder results from a complete or partial defect of the LDL receptor (1) that normally controls the degradation of LDL. Reduction of LDL-cholesterol levels has proved to be effective in decreasing the incidence of CAD (2, 3). Compactin (4) and mevinolin (5), competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, are effective in lowering cholesterol levels of patients with familial hypercholesterolemia. These drugs lower plasma LDL by decreasing the rate of LDL production and stimulating the production of LDL receptor in the liver (6) (Fig. 1). LDL receptor has a specific binding activity\n\nfor apolipoproteins B and E (7). The apolipoprotein B is present in very low-density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and LDL (8), which are highly associated with CAD (9, 10). Apolipoproteins A-I and A-II are primary apolipo-proteins in high-density lipoprotein (HDL) (8), and apolipoprotein A-I in patients with CAD has been demonstrated to be decreased (11).",
"editor": [
{
"familyName": "Paoletti",
"givenName": "Rodolfo",
"type": "Person"
},
{
"familyName": "Kritchevsky",
"givenName": "David",
"type": "Person"
},
{
"familyName": "Holmes",
"givenName": "William L.",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-3-642-71702-4_49",
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-3-642-71704-8",
"978-3-642-71702-4"
],
"name": "Drugs Affecting Lipid Metabolism",
"type": "Book"
},
"keywords": [
"coronary artery disease",
"intermediate density lipoprotein",
"high-density lipoprotein",
"familial hypercholesterolemia",
"LDL receptor",
"apolipoprotein B",
"incidence of CAD",
"low-density lipoprotein cholesterol",
"LDL cholesterol levels",
"serum lipoprotein lipids",
"lower plasma LDL",
"low-density lipoprotein",
"degradation of LDL",
"autosomal dominant disorder",
"lipoprotein cholesterol",
"artery disease",
"tendon xanthomas",
"apolipoprotein levels",
"cholesterol levels",
"lipoprotein lipids",
"plasma LDL",
"LDL production",
"density lipoprotein",
"CS-514",
"hypercholesterolemia",
"patients",
"LDL",
"coenzyme A (HMG-CoA) reductase",
"apolipoprotein A",
"elevated levels",
"dominant disorder",
"lipoprotein",
"receptors",
"term effects",
"partial defect",
"disorders",
"xanthomas",
"levels",
"competitive inhibitor",
"disease",
"incidence",
"liver",
"cholesterol",
"inhibitors",
"A Reductase",
"lipids",
"mevinolin",
"activity",
"rate",
"defects",
"reduction",
"effect",
"production",
"compactin",
"reductase",
"degradation"
],
"name": "Long-Term Effects of CS-514 on Serum Lipoprotein Lipid and Apolipoprotein Levels in Patients with Familial Hypercholesterolemia",
"pagination": "260-268",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1051880374"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-3-642-71702-4_49"
]
}
],
"publisher": {
"name": "Springer Nature",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-3-642-71702-4_49",
"https://app.dimensions.ai/details/publication/pub.1051880374"
],
"sdDataset": "chapters",
"sdDatePublished": "2022-08-04T17:14",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/chapter/chapter_113.jsonl",
"type": "Chapter",
"url": "https://doi.org/10.1007/978-3-642-71702-4_49"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-71702-4_49'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-71702-4_49'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-71702-4_49'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-71702-4_49'
This table displays all metadata directly associated to this object as RDF triples.
173 TRIPLES
22 PREDICATES
81 URIs
74 LITERALS
7 BLANK NODES