Peripheral and Central Nervous System Effects of Nabam and Ethylenethiourea in Rats View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1986

AUTHORS

K. Savolainen , H. Hervonen , H. Komulainen , P. Kurttio

ABSTRACT

Thiurams and dithiocarbamates are neurotoxic and may lead to peripheral motor neuropathy as well as morphological alterations in the central nervous system (CNS) (Sterman and Schaumburg 1980) and in the cholinergic nerves in the gut of rat (Savolainen et al. 1984; Savolainen and Hervonen 1985). Wistar male rats received 0–200 mg/l of nabam and 0–300 mg/1 of ethylenethiourea (ETU), a metabolite of nabam, in drinking water for 28 d. The daily doses for nabam were 8.4–30.5 and for ETU 10.6–34.4 mg/kg. Isolated ilea of all rats showed similar responses to acetylcholine. Nabam decreased the responses of ilea to 5-hydroxytryptamine, whereas the responses were slightly increased by ETU. Both agents tended to increase the responses of the ilea to nicotine. Nabam increased the histochemical reactivity of acetylcholinesterase (AChE) and non-specific cholinesterase of the ilea, whereas ETU had only a marginally decreasing effect on AChE. ETU had no apparent effect on specific 3H-flunitrazepam binding in the rat brain. The present data suggest that cholinergic peripheral nerves rather than the central nervous system (Komulainen and Savolainen, 1985) are targets of neurotoxic effects of dithiocarbamates or their metabolites. More... »

PAGES

345-345

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-71248-7_62

DOI

http://dx.doi.org/10.1007/978-3-642-71248-7_62

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016517671


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