Pharmacokinetics and Interactions of Ciclosporin View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1985

AUTHORS

P. A. Keown , C. R. Stiller , M. Stawecki , J. McMichael , W. Howson

ABSTRACT

Ciclosporin (CyA) is a potent immunosuppressive agent which acts selectively upon the immune response by inhibition of the lymphokine cascade, thus inhibiting cell-cell communication [1]. In addition, augmentation of the inflammatory response is attenuated by blockade of macrophage migration inhibition factor (MIF) and macrophage arming factor (MAF), limiting the delayed-type hypersensitivity response and immunologically nonspecific tissue injury [2]. By virtue of its efficacy and immunologic specificity, CyA is employed extensively in organ transplantation, and also appears to be of major potential importance in the area of auto-immunity. More... »

PAGES

39-42

Book

TITLE

Ciclosporin in Autoimmune Diseases

ISBN

978-3-642-70609-7
978-3-642-70607-3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-70607-3_6

DOI

http://dx.doi.org/10.1007/978-3-642-70607-3_6

DIMENSIONS

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