C4 Haplotypes with Duplicated C4A or C4B: Frequency and Associations with Bf, C2, and HLA-A, B, C, DR Alleles with ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1984

AUTHORS

B. Uring-Lambert , C. M. Giles , J. Goetz , M. M. Tongio , S. Mayer , G. Hauptmann

ABSTRACT

The fourth component of human complement (C4) is encoded by two separate genes, C4A and C4B, located between the HLA-B and HLA-DR loci [4]. The recent technology of C4 typing has allowed the identification of 12 alleles at the C4A locus and 18 alleles at the C4B locus [12]. In addition, “null alleles”, AQO and BQ0, are relatively common at both loci. Duplications at C4A or C4B have also been described [2, 3, 7, 11, 13, 16, 18], and it has been proposed that they have arisen by unequal crossing-over between chromosomes with two expressed genes [1]. More... »

PAGES

604-608

Book

TITLE

Histocompatibility Testing 1984

ISBN

978-3-642-69772-2
978-3-642-69770-8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-69770-8_221

DOI

http://dx.doi.org/10.1007/978-3-642-69770-8_221

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015034463


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