Immune dysregulation and CD4+ T cell loss in HIV-1 infection View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

1997

AUTHORS

Linde Meyaard , Frank Miedema

ABSTRACT

Acquired immunodeficiency syndrome (AIDS) is the clinical outcome of human immunodeficiency virus type 1 or 2 (HIV-1, HIV-2) infection. Acute infection with HIV, which may present with influenza- or mononucleosis-like symptoms [148], is followed by an asymptomatic period of a few months to more than 13 years. This asymptomatic period is characterized by declining numbers of circulating CD4+ T helper (Th) cells, eventually leading to immunodeficiency and clinical symptoms defining the AIDS diagnosis. The symptoms observed may be lymphadenopathy, infections with opportunistic pathogens, neoplasms such as Kaposi sarcoma and non-Hodgkin lymphoma, neurological symptoms and dementia. The opportunistic infections are mainly caused by intracellular pathogens such as viruses, mycobacteria, protozoa and fungi which, as the malignancies observed, are indicative for failing cellular immunity. More... »

PAGES

33-51

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-60867-4_4

DOI

http://dx.doi.org/10.1007/978-3-642-60867-4_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039036690


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