UV-Radiation and Urocanic Acid View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

F. de Fine Olivarius

ABSTRACT

Urocanic acid (UCA) is synthezised from histidine as trans-UCA, which accumulates in the epidermis where urocanase is absent. On ultraviolet (UV) irradiation photoisomerization of trans-UCA to its cis-isomer takes place in a dose-dependent fashion, until a photostationary state with approximately equal quantities of the two isomers is reached. The appreciable quantities of trans-UCA in the stratum corneum together with the demonstration of its UV-absorbing properties, originally lead to the proposal that UCA plays a role in natural photoprotection, acting as a naturally occurring sunscreening agent. In recent years the interest has however been focused on the immunomodulating properties of cis-UCA, which may be the prime function of UCA. More... »

PAGES

131-136

Book

TITLE

Skin Cancer and UV Radiation

ISBN

978-3-642-64547-1
978-3-642-60771-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-60771-4_15

DOI

http://dx.doi.org/10.1007/978-3-642-60771-4_15

DIMENSIONS

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