Neutrophil Elastase, C-Reactive Protein and Platelet Count After Severe Multiple Trauma Indicate the Risk for Late Multiple Organ Failure Following ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

C. Waydhas , D. Nast-Kolb , R. Zettl , A. Trupka , L. Schweiberer , M. Jochum

ABSTRACT

The objective of this study was to determine the role of both specific and non-specific indicators of the inflammatory response in their ability to indicate the risk of patients with severe multiple injuries of developing late organ failure following secondary operations. In a prospective study of 106 severely injured patients (mean injury severity score, ISS, 40.6) who underwent secondary operations (>3 days after trauma), we compared the level of preoperative inflammation with the sequelae of surgical trauma. The interventions included facial reconstructions, osteosynthesis of the pelvic girdle, long bones and spine, and others. Group 1 comprised 40 patients (38%) who developed respiratory, renal and/or hepatic failure within 2 days after the operation or whose pre-existing organ dysfunction worsened by more than 20% from baseline. The remaining 66 patients (62%) with an uneventful recovery formed group 2. The preoperative levels of neutrophil elastase (92.2 vs. 61.3 ng/dl), C-reactive protein (12.4 vs. 7.6 mg/dl) and platelet count (118 vs. 236 1000/jil) were significantly more abnormal in the patients in group 1. The pO2 to FiO2 ratio was also somewhat lower in group 1 patients (305.5 vs. 351), whereas other parameters, e.g. cathepsin B, interleukin (IL)-6, blood pressure, heart rate, bilirubin, creatinine, urinary output, lactate, pH and coagulation, were not able to differentiate preoperatively between groups 1 and 2. An increased state of inflammation (neutrophil elastase, >85 ng/ml; C-reactive protein, >11 mg/dl; platelet count, <180 000/µl) predicted postoperative organ failure with an accuracy of 79% (sensitivity, 73%; specificity, 83%). In conclusion, secondary operations may act as a second hit and precipitate late multiple organ dysfunction syndrome if they are done in multi-trauma patients while the patients still have an increased level of post-traumatic inflammation. If the levels of neutrophil elastase and C-reactive protein are elevated and the platelet count is low, a further delay of surgery or a change of method might be beneficial. More... »

PAGES

43-55

Book

TITLE

Advances in Critical Care Testing

ISBN

978-3-540-62590-2
978-3-642-60735-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-60735-6_5

DOI

http://dx.doi.org/10.1007/978-3-642-60735-6_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050772192


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Waydhas", 
        "givenName": "C.", 
        "id": "sg:person.012715640474.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012715640474.43"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Nast-Kolb", 
        "givenName": "D.", 
        "id": "sg:person.01247004507.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247004507.31"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Zettl", 
        "givenName": "R.", 
        "id": "sg:person.01020063161.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020063161.50"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Trupka", 
        "givenName": "A.", 
        "id": "sg:person.0735564416.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735564416.70"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Schweiberer", 
        "givenName": "L.", 
        "id": "sg:person.01264425106.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264425106.78"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Jochum", 
        "givenName": "M.", 
        "id": "sg:person.0637121716.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637121716.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejm197507312930501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000112207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198903000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000592874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198903000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000592874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198903000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000592874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1992.01420040106019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002652627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800721002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005562618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.4780060402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008021241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.96.5.1153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008795032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198909000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008805194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198909000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008805194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199308000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009389481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199308000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009389481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1990.01410160084019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012084829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-197909000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016855349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-197909000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016855349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-197909000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016855349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1986.01400080028004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017407640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0300-9572(91)90044-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018764276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199012001-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021392902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199012001-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021392902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-198309000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023073559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-198309000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023073559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm197710202971601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027984940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198509000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029467063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198509000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029467063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1985.01390340007001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035229546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0001-2998(78)80014-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035405952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199012001-00033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038052177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199012001-00033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038052177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198907000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038222383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198907000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038222383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(05)80664-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045599331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198206000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046102450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-198206000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046102450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199001000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047365467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199001000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047365467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1980.01380020006003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047520080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0039-6109(16)43681-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051065363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199304000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052114956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199304000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052114956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/00000539-197007000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053139888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.147.7.1273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054111730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs0790161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056725962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs0790161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056725962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-198971030-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068890047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075976091", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077287800", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077878908", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078802267", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079391814", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079455600", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079610479", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082163195", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082463515", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082645569", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997", 
    "datePublishedReg": "1997-01-01", 
    "description": "The objective of this study was to determine the role of both specific and non-specific indicators of the inflammatory response in their ability to indicate the risk of patients with severe multiple injuries of developing late organ failure following secondary operations. In a prospective study of 106 severely injured patients (mean injury severity score, ISS, 40.6) who underwent secondary operations (>3 days after trauma), we compared the level of preoperative inflammation with the sequelae of surgical trauma. The interventions included facial reconstructions, osteosynthesis of the pelvic girdle, long bones and spine, and others. Group 1 comprised 40 patients (38%) who developed respiratory, renal and/or hepatic failure within 2 days after the operation or whose pre-existing organ dysfunction worsened by more than 20% from baseline. The remaining 66 patients (62%) with an uneventful recovery formed group 2. The preoperative levels of neutrophil elastase (92.2 vs. 61.3 ng/dl), C-reactive protein (12.4 vs. 7.6 mg/dl) and platelet count (118 vs. 236 1000/jil) were significantly more abnormal in the patients in group 1. The pO2 to FiO2 ratio was also somewhat lower in group 1 patients (305.5 vs. 351), whereas other parameters, e.g. cathepsin B, interleukin (IL)-6, blood pressure, heart rate, bilirubin, creatinine, urinary output, lactate, pH and coagulation, were not able to differentiate preoperatively between groups 1 and 2. An increased state of inflammation (neutrophil elastase, >85 ng/ml; C-reactive protein, >11 mg/dl; platelet count, <180 000/\u00b5l) predicted postoperative organ failure with an accuracy of 79% (sensitivity, 73%; specificity, 83%). In conclusion, secondary operations may act as a second hit and precipitate late multiple organ dysfunction syndrome if they are done in multi-trauma patients while the patients still have an increased level of post-traumatic inflammation. If the levels of neutrophil elastase and C-reactive protein are elevated and the platelet count is low, a further delay of surgery or a change of method might be beneficial.", 
    "editor": [
      {
        "familyName": "List", 
        "givenName": "W. F.", 
        "type": "Person"
      }, 
      {
        "familyName": "M\u00fcller", 
        "givenName": "M. M.", 
        "type": "Person"
      }, 
      {
        "familyName": "McQueen", 
        "givenName": "M. J.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-642-60735-6_5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-540-62590-2", 
        "978-3-642-60735-6"
      ], 
      "name": "Advances in Critical Care Testing", 
      "type": "Book"
    }, 
    "name": "Neutrophil Elastase, C-Reactive Protein and Platelet Count After Severe Multiple Trauma Indicate the Risk for Late Multiple Organ Failure Following Secondary Operations", 
    "pagination": "43-55", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050772192"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-642-60735-6_5"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f1dbb3c4630fef49a18c8c8df2b5df332d491424d8c632f314bcd3b209276547"
        ]
      }
    ], 
    "publisher": {
      "location": "Berlin, Heidelberg", 
      "name": "Springer Berlin Heidelberg", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-642-60735-6_5", 
      "https://app.dimensions.ai/details/publication/pub.1050772192"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T09:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117125_00000002.jsonl", 
    "type": "Chapter", 
    "url": "https://link.springer.com/10.1007%2F978-3-642-60735-6_5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-60735-6_5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-60735-6_5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-60735-6_5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-60735-6_5'


 

This table displays all metadata directly associated to this object as RDF triples.

211 TRIPLES      23 PREDICATES      67 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-642-60735-6_5 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N017b8e284a16408080faae2bab203665
4 schema:citation https://app.dimensions.ai/details/publication/pub.1075976091
5 https://app.dimensions.ai/details/publication/pub.1077287800
6 https://app.dimensions.ai/details/publication/pub.1077878908
7 https://app.dimensions.ai/details/publication/pub.1078802267
8 https://app.dimensions.ai/details/publication/pub.1079391814
9 https://app.dimensions.ai/details/publication/pub.1079455600
10 https://app.dimensions.ai/details/publication/pub.1079610479
11 https://app.dimensions.ai/details/publication/pub.1082163195
12 https://app.dimensions.ai/details/publication/pub.1082463515
13 https://app.dimensions.ai/details/publication/pub.1082645569
14 https://doi.org/10.1001/archinte.147.7.1273
15 https://doi.org/10.1001/archsurg.1980.01380020006003
16 https://doi.org/10.1001/archsurg.1985.01390340007001
17 https://doi.org/10.1001/archsurg.1986.01400080028004
18 https://doi.org/10.1001/archsurg.1990.01410160084019
19 https://doi.org/10.1001/archsurg.1992.01420040106019
20 https://doi.org/10.1002/bjs.1800721002
21 https://doi.org/10.1002/sim.4780060402
22 https://doi.org/10.1016/0300-9572(91)90044-y
23 https://doi.org/10.1016/s0001-2998(78)80014-2
24 https://doi.org/10.1016/s0002-9610(05)80664-6
25 https://doi.org/10.1016/s0039-6109(16)43681-9
26 https://doi.org/10.1042/cs0790161
27 https://doi.org/10.1056/nejm197507312930501
28 https://doi.org/10.1056/nejm197710202971601
29 https://doi.org/10.1097/00000658-197909000-00004
30 https://doi.org/10.1097/00000658-198509000-00003
31 https://doi.org/10.1097/00000658-198907000-00011
32 https://doi.org/10.1097/00000658-198909000-00012
33 https://doi.org/10.1097/00003246-198206000-00013
34 https://doi.org/10.1097/00003246-198903000-00004
35 https://doi.org/10.1097/00005373-198309000-00002
36 https://doi.org/10.1097/00005373-199001000-00015
37 https://doi.org/10.1097/00005373-199012001-00012
38 https://doi.org/10.1097/00005373-199012001-00033
39 https://doi.org/10.1097/00005373-199304000-00010
40 https://doi.org/10.1097/00005373-199308000-00008
41 https://doi.org/10.1213/00000539-197007000-00010
42 https://doi.org/10.1378/chest.96.5.1153
43 https://doi.org/10.2106/00004623-198971030-00004
44 schema:datePublished 1997
45 schema:datePublishedReg 1997-01-01
46 schema:description The objective of this study was to determine the role of both specific and non-specific indicators of the inflammatory response in their ability to indicate the risk of patients with severe multiple injuries of developing late organ failure following secondary operations. In a prospective study of 106 severely injured patients (mean injury severity score, ISS, 40.6) who underwent secondary operations (>3 days after trauma), we compared the level of preoperative inflammation with the sequelae of surgical trauma. The interventions included facial reconstructions, osteosynthesis of the pelvic girdle, long bones and spine, and others. Group 1 comprised 40 patients (38%) who developed respiratory, renal and/or hepatic failure within 2 days after the operation or whose pre-existing organ dysfunction worsened by more than 20% from baseline. The remaining 66 patients (62%) with an uneventful recovery formed group 2. The preoperative levels of neutrophil elastase (92.2 vs. 61.3 ng/dl), C-reactive protein (12.4 vs. 7.6 mg/dl) and platelet count (118 vs. 236 1000/jil) were significantly more abnormal in the patients in group 1. The pO2 to FiO2 ratio was also somewhat lower in group 1 patients (305.5 vs. 351), whereas other parameters, e.g. cathepsin B, interleukin (IL)-6, blood pressure, heart rate, bilirubin, creatinine, urinary output, lactate, pH and coagulation, were not able to differentiate preoperatively between groups 1 and 2. An increased state of inflammation (neutrophil elastase, >85 ng/ml; C-reactive protein, >11 mg/dl; platelet count, <180 000/µl) predicted postoperative organ failure with an accuracy of 79% (sensitivity, 73%; specificity, 83%). In conclusion, secondary operations may act as a second hit and precipitate late multiple organ dysfunction syndrome if they are done in multi-trauma patients while the patients still have an increased level of post-traumatic inflammation. If the levels of neutrophil elastase and C-reactive protein are elevated and the platelet count is low, a further delay of surgery or a change of method might be beneficial.
47 schema:editor Nabbd8c9c9365479d9f5e1165462ad0cc
48 schema:genre chapter
49 schema:inLanguage en
50 schema:isAccessibleForFree false
51 schema:isPartOf N35fbea6d83594cefa4ccb1e0378c38e0
52 schema:name Neutrophil Elastase, C-Reactive Protein and Platelet Count After Severe Multiple Trauma Indicate the Risk for Late Multiple Organ Failure Following Secondary Operations
53 schema:pagination 43-55
54 schema:productId N0aab7aa89fd34b409c5092663165291c
55 N32bd5eff2c554578afd4831ea8f05c76
56 N6bcfbdc21d2040c4ac1ea36851bf3f2c
57 schema:publisher Nfa13be0b8b7344c1818a8265ac2b199d
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050772192
59 https://doi.org/10.1007/978-3-642-60735-6_5
60 schema:sdDatePublished 2019-04-16T09:31
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N78c30aab4c4948e68f1698cc046ff750
63 schema:url https://link.springer.com/10.1007%2F978-3-642-60735-6_5
64 sgo:license sg:explorer/license/
65 sgo:sdDataset chapters
66 rdf:type schema:Chapter
67 N017b8e284a16408080faae2bab203665 rdf:first sg:person.012715640474.43
68 rdf:rest N40d2ac8690884e1a811116ce91757499
69 N0aab7aa89fd34b409c5092663165291c schema:name readcube_id
70 schema:value f1dbb3c4630fef49a18c8c8df2b5df332d491424d8c632f314bcd3b209276547
71 rdf:type schema:PropertyValue
72 N32bd5eff2c554578afd4831ea8f05c76 schema:name dimensions_id
73 schema:value pub.1050772192
74 rdf:type schema:PropertyValue
75 N35fbea6d83594cefa4ccb1e0378c38e0 schema:isbn 978-3-540-62590-2
76 978-3-642-60735-6
77 schema:name Advances in Critical Care Testing
78 rdf:type schema:Book
79 N40d2ac8690884e1a811116ce91757499 rdf:first sg:person.01247004507.31
80 rdf:rest N4f8ab0fdbd014c15bff0fd51b381c01c
81 N4f1d5be775964beca88b9fb761314775 rdf:first sg:person.0735564416.70
82 rdf:rest N76a520045e8a46579bdee6db7e343882
83 N4f8ab0fdbd014c15bff0fd51b381c01c rdf:first sg:person.01020063161.50
84 rdf:rest N4f1d5be775964beca88b9fb761314775
85 N6bcfbdc21d2040c4ac1ea36851bf3f2c schema:name doi
86 schema:value 10.1007/978-3-642-60735-6_5
87 rdf:type schema:PropertyValue
88 N76a520045e8a46579bdee6db7e343882 rdf:first sg:person.01264425106.78
89 rdf:rest N9f912763036d4a21bb08b8061f2c0f39
90 N786c6a68a0ab44399171584b3f8f2344 rdf:first N857c75e76e9648829773a0aa1eb64d63
91 rdf:rest rdf:nil
92 N78c30aab4c4948e68f1698cc046ff750 schema:name Springer Nature - SN SciGraph project
93 rdf:type schema:Organization
94 N7fc6585549a44b368fc354b8e242100c schema:familyName List
95 schema:givenName W. F.
96 rdf:type schema:Person
97 N857c75e76e9648829773a0aa1eb64d63 schema:familyName McQueen
98 schema:givenName M. J.
99 rdf:type schema:Person
100 N9f912763036d4a21bb08b8061f2c0f39 rdf:first sg:person.0637121716.02
101 rdf:rest rdf:nil
102 Nabbd8c9c9365479d9f5e1165462ad0cc rdf:first N7fc6585549a44b368fc354b8e242100c
103 rdf:rest Ne409d8dd334c4f249103f132a15bbd2e
104 Ne10d27de45e24bc295cae3a113f12359 schema:familyName Müller
105 schema:givenName M. M.
106 rdf:type schema:Person
107 Ne409d8dd334c4f249103f132a15bbd2e rdf:first Ne10d27de45e24bc295cae3a113f12359
108 rdf:rest N786c6a68a0ab44399171584b3f8f2344
109 Nfa13be0b8b7344c1818a8265ac2b199d schema:location Berlin, Heidelberg
110 schema:name Springer Berlin Heidelberg
111 rdf:type schema:Organisation
112 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
113 schema:name Medical and Health Sciences
114 rdf:type schema:DefinedTerm
115 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
116 schema:name Clinical Sciences
117 rdf:type schema:DefinedTerm
118 sg:person.01020063161.50 schema:familyName Zettl
119 schema:givenName R.
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020063161.50
121 rdf:type schema:Person
122 sg:person.01247004507.31 schema:familyName Nast-Kolb
123 schema:givenName D.
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247004507.31
125 rdf:type schema:Person
126 sg:person.01264425106.78 schema:familyName Schweiberer
127 schema:givenName L.
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264425106.78
129 rdf:type schema:Person
130 sg:person.012715640474.43 schema:familyName Waydhas
131 schema:givenName C.
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012715640474.43
133 rdf:type schema:Person
134 sg:person.0637121716.02 schema:familyName Jochum
135 schema:givenName M.
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637121716.02
137 rdf:type schema:Person
138 sg:person.0735564416.70 schema:familyName Trupka
139 schema:givenName A.
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735564416.70
141 rdf:type schema:Person
142 https://app.dimensions.ai/details/publication/pub.1075976091 schema:CreativeWork
143 https://app.dimensions.ai/details/publication/pub.1077287800 schema:CreativeWork
144 https://app.dimensions.ai/details/publication/pub.1077878908 schema:CreativeWork
145 https://app.dimensions.ai/details/publication/pub.1078802267 schema:CreativeWork
146 https://app.dimensions.ai/details/publication/pub.1079391814 schema:CreativeWork
147 https://app.dimensions.ai/details/publication/pub.1079455600 schema:CreativeWork
148 https://app.dimensions.ai/details/publication/pub.1079610479 schema:CreativeWork
149 https://app.dimensions.ai/details/publication/pub.1082163195 schema:CreativeWork
150 https://app.dimensions.ai/details/publication/pub.1082463515 schema:CreativeWork
151 https://app.dimensions.ai/details/publication/pub.1082645569 schema:CreativeWork
152 https://doi.org/10.1001/archinte.147.7.1273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054111730
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1001/archsurg.1980.01380020006003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047520080
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1001/archsurg.1985.01390340007001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035229546
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1001/archsurg.1986.01400080028004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017407640
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1001/archsurg.1990.01410160084019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012084829
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1001/archsurg.1992.01420040106019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002652627
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1002/bjs.1800721002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005562618
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1002/sim.4780060402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008021241
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/0300-9572(91)90044-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1018764276
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/s0001-2998(78)80014-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035405952
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/s0002-9610(05)80664-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045599331
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/s0039-6109(16)43681-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051065363
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1042/cs0790161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056725962
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1056/nejm197507312930501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000112207
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1056/nejm197710202971601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027984940
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1097/00000658-197909000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016855349
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1097/00000658-198509000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029467063
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1097/00000658-198907000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038222383
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1097/00000658-198909000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008805194
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1097/00003246-198206000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046102450
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1097/00003246-198903000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000592874
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1097/00005373-198309000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023073559
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1097/00005373-199001000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047365467
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1097/00005373-199012001-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021392902
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1097/00005373-199012001-00033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038052177
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/00005373-199304000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052114956
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/00005373-199308000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009389481
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1213/00000539-197007000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053139888
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1378/chest.96.5.1153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008795032
209 rdf:type schema:CreativeWork
210 https://doi.org/10.2106/00004623-198971030-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068890047
211 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...