Ontology type: schema:Chapter
1997
AUTHORSE. R. Panzer-Grümayer , D. Ghali , S. Panzer , S. Fischer , A. Argyriou-Tirita , O. A. Haas , H. Kovar , H. Gadner
ABSTRACTAcute B cell precursor leukemias (BALLs) have been demonstrated by Southern blot hybridization to be oligoclonal at the IgH gene level in up to 40% of cases. In contrast, oligoclonality as deduced from diversity of the TcR-d gene rearrangements of the immature types has not been reported so far. In 4 of 20 cases of childhood BCP-ALL we detected oligoclonality characterized by the coexistence of different junctional regions varying in size by 3-25 nucleotides of identical Vd2-Dd3 rearrangements. No variation was found in the IgH and TcR-g gene status. Two cases displayed the variants in an unequal proportion, while in the last two, in which similar quantities of the coexisting rearrangements were detected, single-cell nuclei (PCR) revealed two separate leukemic populations. The variants arose independently of each other as deduced from their individual sequences. We postulate that in these leukemic cell populations TcR-d gene diversity arose after rearrangements of the IgH genes, resulting in apparent clonality at the IgH gene level. However, cells are oligoclonal if the TcR-d gene rearrangements are taken into account. More... »
PAGES102-106
Acute Leukemias VI
ISBN
978-3-642-64379-8
978-3-642-60377-8
http://scigraph.springernature.com/pub.10.1007/978-3-642-60377-8_17
DOIhttp://dx.doi.org/10.1007/978-3-642-60377-8_17
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1019247269
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.416346.2",
"name": [
"Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Panzer-Gr\u00fcmayer",
"givenName": "E. R.",
"id": "sg:person.01173521605.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173521605.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.416346.2",
"name": [
"Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Ghali",
"givenName": "D.",
"id": "sg:person.01043316350.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043316350.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Blood Group Serology, University of Vienna, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.10420.37",
"name": [
"Department of Blood Group Serology, University of Vienna, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Panzer",
"givenName": "S.",
"id": "sg:person.01352341620.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352341620.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.416346.2",
"name": [
"Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Fischer",
"givenName": "S.",
"id": "sg:person.01157500351.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157500351.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.416346.2",
"name": [
"Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Argyriou-Tirita",
"givenName": "A.",
"id": "sg:person.0622153240.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622153240.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.416346.2",
"name": [
"Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Haas",
"givenName": "O. A.",
"id": "sg:person.0707201504.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707201504.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.416346.2",
"name": [
"Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Kovar",
"givenName": "H.",
"id": "sg:person.0741362200.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741362200.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.416346.2",
"name": [
"Children\u2019s Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Gadner",
"givenName": "H.",
"id": "sg:person.01056544701.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056544701.13"
],
"type": "Person"
}
],
"datePublished": "1997",
"datePublishedReg": "1997-01-01",
"description": "Acute B cell precursor leukemias (BALLs) have been demonstrated by Southern blot hybridization to be oligoclonal at the IgH gene level in up to 40% of cases. In contrast, oligoclonality as deduced from diversity of the TcR-d gene rearrangements of the immature types has not been reported so far. In 4 of 20 cases of childhood BCP-ALL we detected oligoclonality characterized by the coexistence of different junctional regions varying in size by 3-25 nucleotides of identical Vd2-Dd3 rearrangements. No variation was found in the IgH and TcR-g gene status. Two cases displayed the variants in an unequal proportion, while in the last two, in which similar quantities of the coexisting rearrangements were detected, single-cell nuclei (PCR) revealed two separate leukemic populations. The variants arose independently of each other as deduced from their individual sequences. We postulate that in these leukemic cell populations TcR-d gene diversity arose after rearrangements of the IgH genes, resulting in apparent clonality at the IgH gene level. However, cells are oligoclonal if the TcR-d gene rearrangements are taken into account.",
"editor": [
{
"familyName": "B\u00fcchner",
"givenName": "T.",
"type": "Person"
},
{
"familyName": "Schellong",
"givenName": "G.",
"type": "Person"
},
{
"familyName": "Ritter",
"givenName": "J.",
"type": "Person"
},
{
"familyName": "Creutzig",
"givenName": "U.",
"type": "Person"
},
{
"familyName": "Hiddemann",
"givenName": "W.",
"type": "Person"
},
{
"familyName": "W\u00f6rmann",
"givenName": "B.",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-3-642-60377-8_17",
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-3-642-64379-8",
"978-3-642-60377-8"
],
"name": "Acute Leukemias VI",
"type": "Book"
},
"keywords": [
"gene level",
"B-cell precursor leukemia",
"gene rearrangements",
"gene diversity",
"single cell nuclei",
"Southern blot hybridization",
"blot hybridization",
"diversity",
"IgH gene",
"rearrangement",
"individual sequences",
"unequal proportions",
"gene status",
"subclone formation",
"apparent clonality",
"junctional region",
"genes",
"nucleotides",
"variants",
"leukemic population",
"hybridization",
"sequence",
"similar quantities",
"IgH",
"cells",
"clonality",
"TCR",
"nucleus",
"immature type",
"levels",
"population",
"leukemia",
"region",
"variation",
"contrast",
"coexistence",
"formation",
"oligoclonality",
"childhood BCP",
"proportion",
"types",
"size",
"status",
"quantity",
"BCP",
"cases",
"account"
],
"name": "Diversity of the TcR-d Gene Rearrangements Indicates Subclone Formation in Acute B Cell Precursor Leukemias",
"pagination": "102-106",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1019247269"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-3-642-60377-8_17"
]
}
],
"publisher": {
"name": "Springer Nature",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-3-642-60377-8_17",
"https://app.dimensions.ai/details/publication/pub.1019247269"
],
"sdDataset": "chapters",
"sdDatePublished": "2022-08-04T17:18",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/chapter/chapter_350.jsonl",
"type": "Chapter",
"url": "https://doi.org/10.1007/978-3-642-60377-8_17"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-60377-8_17'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-60377-8_17'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-60377-8_17'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-60377-8_17'
This table displays all metadata directly associated to this object as RDF triples.
183 TRIPLES
22 PREDICATES
72 URIs
65 LITERALS
7 BLANK NODES