Diversity of the TcR-d Gene Rearrangements Indicates Subclone Formation in Acute B Cell Precursor Leukemias View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

E. R. Panzer-Grümayer , D. Ghali , S. Panzer , S. Fischer , A. Argyriou-Tirita , O. A. Haas , H. Kovar , H. Gadner

ABSTRACT

Acute B cell precursor leukemias (BALLs) have been demonstrated by Southern blot hybridization to be oligoclonal at the IgH gene level in up to 40% of cases. In contrast, oligoclonality as deduced from diversity of the TcR-d gene rearrangements of the immature types has not been reported so far. In 4 of 20 cases of childhood BCP-ALL we detected oligoclonality characterized by the coexistence of different junctional regions varying in size by 3-25 nucleotides of identical Vd2-Dd3 rearrangements. No variation was found in the IgH and TcR-g gene status. Two cases displayed the variants in an unequal proportion, while in the last two, in which similar quantities of the coexisting rearrangements were detected, single-cell nuclei (PCR) revealed two separate leukemic populations. The variants arose independently of each other as deduced from their individual sequences. We postulate that in these leukemic cell populations TcR-d gene diversity arose after rearrangements of the IgH genes, resulting in apparent clonality at the IgH gene level. However, cells are oligoclonal if the TcR-d gene rearrangements are taken into account. More... »

PAGES

102-106

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-60377-8_17

DOI

http://dx.doi.org/10.1007/978-3-642-60377-8_17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019247269


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