The Import of Cytosolic tRNA into Plant Mitochondria View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1999

AUTHORS

L. Maréchal-Drouard , A. Dietrich , H. Mireau , N. Peeters , I. Small

ABSTRACT

A consideration of the sparse genetic information carried by mitochondrial genomes illustrates why these organelles are so dependent on the rest of the cell, as most of the proteins necessary for their function are encoded by the nuclear genome and imported from the cytosol. However, certain protein components of the respiratory chain complexes and (in some cases) a few ribosomal proteins are synthesized by the mitochondrial translation machinery. Hence, the mitochondrial translation system must include a full set of transfer RNAs (tRNAs) to ensure the incorporation of the usual 20 amino acids into the polypeptides being synthesized. Vascular plant mitochondrial genomes contain at most 12 to 14 functional “native” tRNA genes deriving from the genome of the original endosymbiotic bacterium (Sangaré et al. 1990; Weber-Lotfi et al. 1993; Ceci et al. 1996; Unseld et al. 1997). These genes are obviously insufficient to cover the needs of the mitochondrial translation system. To get round this problem, plant mitochondria use tRNAs that have to be imported from the cytosol (Dietrich et al. 1992; Kumar et al. 1996). This specific transport of nucleic acids across the double mitochondrial membrane occurs in many diverse organisms, including plants, some fungi and protozoa (Schneider 1994), and it can be expected that a sufficient understanding of the tRNA import mechanism will permit the development of a strategy for gene therapy of human cytopathies such as MELAS or MERRF provoked by mutations in mitochondrial tRNA genes. More... »

PAGES

317-326

References to SciGraph publications

  • 1998-03. Structure and expression of several bean (Phaseolus vulgaris) nuclear transfer RNA genes: relevance to the process of tRNA import into plant mitochondria in PLANT MOLECULAR BIOLOGY
  • 1998-04. A tRNA suppressor mutation in human mitochondria in NATURE GENETICS
  • 1998-09. Two birds with one stone: genes that encode products targeted to two or more compartments in PLANT MOLECULAR BIOLOGY
  • 1995-05. MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNALys and premature translation termination in NATURE GENETICS
  • 1996-09. Striking differences in mitochondrial tRNA import between different plant species in MOLECULAR GENETICS AND GENOMICS
  • 1986-01. Two dimensional polyacrylamide gel electrophoresis analysis of Tetrahymena mitochondrial tRNA in CURRENT GENETICS
  • 1994-12. Characterization of some major identity elements in plant alanine and phenylalanine transfer RNAs in PLANT MOLECULAR BIOLOGY
  • 1990-09. Localization and organization of tRNA genes on the mitochondrial genomes of fertile and male sterile lines of maize in MOLECULAR GENETICS AND GENOMICS
  • 1993-01. Localization of tRNA genes on the Petunia hybrida 3704 mitochondrial genome in PLANT MOLECULAR BIOLOGY
  • 1997-01. The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides in NATURE GENETICS
  • 1990-09. Mitochondrial DNA of Chlamydomonas reinhardtii: The gene for apocytochrome b and the complete functional map of the 15.8 kb DNA in MOLECULAR GENETICS AND GENOMICS
  • 1990-12. A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies in NATURE
  • Book

    TITLE

    Mitochondrial Diseases

    ISBN

    978-3-642-64166-4
    978-3-642-59884-5

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-642-59884-5_24

    DOI

    http://dx.doi.org/10.1007/978-3-642-59884-5_24

    DIMENSIONS

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