Role of Platelet-Derived Growth Factors in Angiogenesis and Alveogenesis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1999

AUTHORS

P. Lindahl , H. Boström , L. Karlsson , M. Hellström , M. Kalén , C. Betsholtz

ABSTRACT

Platelet-derived growth factors (PGDFs) are 30-kDa dimeric proteins that exert their functions by binding to and activating PDGF receptors in the cell membrane [12, 22]. Two different PDGF monomers exist; the A chain and the B chain, and these may assemble into AA and BB homodimers as well as AB heterodimers. The two known PDGF-receptor proteins, the PDGF-α receptor (PDGF-Rα) and the β receptor (PDGF-Rβ) are both receptor tyrosine kinases and interact differentially with the PDGF molecules; PDGF-Rβ binds only the PDGF B chain with high affinity, whereas PDGF-Rα binds both chains with high affinity. Accordingly, the different PDGF dimers may bind to, dimerize and signal through different receptor pairs. Dimerization of the receptors is a prerequisite for signaling, since it allows for tyrosine phosphorylation of the intracellular part of the receptor molecules [11]. The resulting phosphotyrosine residues constitute binding sites for molecules carrying src-homology-2 (SH2) and other phosphotyrosine-binding domains. Their association with the PDGF receptor is a critical step in downstream signaling [5, 13]. More... »

PAGES

27-33

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-58456-5_4

DOI

http://dx.doi.org/10.1007/978-3-642-58456-5_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045638965

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10339896


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