The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2001

AUTHORS

Joseph Avruch , Christopher Belham , Qing-Peng Weng , Kenta Hara , Kazuyoshi Yonezawa

ABSTRACT

The p70 S6 kinase was one of the first insulin/mitogen activated protein (Ser/Thr) kinases to be described. The kinase was purified to homogeneity over a decade ago, its molecular structure defined and the enzymology of its phosphorylation of the 40 S subunit protein S6 well worked out, both in vitro and in vivo. By contrast, the cellular function of the kinase, the mechanisms of activation and the nature of the signal transduction elements upstream have been elucidated only within the last several years. This review will describe our current understanding of the biologic role of the p70 kinase as gleaned from experiments in mammalian cell culture, and through gene deletion in mouse and Drosophila, as well as the regulation of the p70 kinase and the nature of the signal transduction pathways that funnel into the control of this ubiquitous signal-responsive ribosomal protein kinase More... »

PAGES

115-154

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-56688-2_5

DOI

http://dx.doi.org/10.1007/978-3-642-56688-2_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047225653

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11575164


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