Single-Molecule Dynamics in Biosystems View Full Text


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Chapter Info

DATE

2001

AUTHORS

T. Yanagida

ABSTRACT

Biomolecules assemble to form molecular machines such as molecular motors, cell signal processors, DNA transcription processors and protein synthesizers to fulfill their functions. Their collaboration allows the activity of biological systems. The reactions and behaviors of molecular machines must be flexible in order to respond to their surroundings. This flexibility is essential for biological organisms. The underlying mechanism of molecular machines is not as simple as one would predict from analogy to man-made machines. Since molecular machines are only nanometers in size and have a flexible structure, they are very prone to thermal agitation. Molecular machines operate under a strong influence of thermal noise, with a high efficiency of energy conversion [1]. This is in sharp contrast to man-made machines that operate precisely and rapidly at energies much higher than thermal noise. The aim of our research is to approach the essential engineering principle of the adaptive biological systems by uncovering the unique operations of molecular machines. For this aim, we have developed several new technologies for single-molecule imaging and manipulation of biomolecules. These new techniques allow the dynamic properties of individual molecules in molecular machines, which were previously hidden in averaged ensemble measurements, to be unveiled [2, 3, 4]. I will survey the applications of single-molecule detection (SMD) techniques to several biological molecular machines and briefly discuss the unique mechanism of motion underlying molecular motors, the system on which SMD has been most successfully used. More... »

PAGES

293-312

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-56544-1_17

DOI

http://dx.doi.org/10.1007/978-3-642-56544-1_17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048814129


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