Hepatic Tumors in Childhood View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014-03-11

AUTHORS

Milton J. Finegold , Dolores H. López-Terrada

ABSTRACT

Great progress in the treatment of hepatoblastoma and some other tumors of the liver in children has been achieved in the past quarter century. Mostly, the benefits have derived from cis-platinum-based chemotherapy for neoplasms and propranolol for infantile hemangiomas. With the advances has come the recognition that thorough histopathologic characterization of HB has prognostic significance and should influence the choice of therapy. These advances have done less for disease that is all too often disseminated at presentation, including most hepatocellular carcinomas and the small undifferentiated cell and rhabdoid variants of HB. The rarity of the tumors has led to increasing international collaboration among all disciplines to address the outstanding issues. Molecular genetic research on pathways of gene expression is providing insights into carcinogenesis and will lead to therapies that avoid the toxicity of current regimens while more effectively attacking the neoplastic cells. But traditional morphologic diagnoses and complete surgical extirpation, including transplantation, remain essential. This chapter summarizes the current data on the antecedent and acquired genetic abnormalities in liver tumors while emphasizing those aspects of histopathology that are essential for diagnostic accuracy and prognosis. More... »

PAGES

547-614

Book

TITLE

Pathology of Pediatric Gastrointestinal and Liver Disease

ISBN

978-3-642-54052-3
978-3-642-54053-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-54053-0_14

DOI

http://dx.doi.org/10.1007/978-3-642-54053-0_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014905894


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Department of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finegold", 
        "givenName": "Milton J.", 
        "id": "sg:person.014103516477.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014103516477.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Department of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f3pez-Terrada", 
        "givenName": "Dolores H.", 
        "id": "sg:person.014633403267.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014633403267.66"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2014-03-11", 
    "datePublishedReg": "2014-03-11", 
    "description": "Great progress in the treatment of hepatoblastoma and some other tumors of the liver in children has been achieved in the past quarter century. Mostly, the benefits have derived from cis-platinum-based chemotherapy for neoplasms and propranolol for infantile hemangiomas. With the advances has come the recognition that thorough histopathologic characterization of HB has prognostic significance and should influence the choice of therapy. These advances have done less for disease that is all too often disseminated at presentation, including most hepatocellular carcinomas and the small undifferentiated cell and rhabdoid variants of HB. The rarity of the tumors has led to increasing international collaboration among all disciplines to address the outstanding issues. Molecular genetic research on pathways of gene expression is providing insights into carcinogenesis and will lead to therapies that avoid the toxicity of current regimens while more effectively attacking the neoplastic cells. But traditional morphologic diagnoses and complete surgical extirpation, including transplantation, remain essential. This chapter summarizes the current data on the antecedent and acquired genetic abnormalities in liver tumors while emphasizing those aspects of histopathology that are essential for diagnostic accuracy and prognosis.", 
    "editor": [
      {
        "familyName": "Russo", 
        "givenName": "Pierre", 
        "type": "Person"
      }, 
      {
        "familyName": "Ruchelli", 
        "givenName": "Eduardo D.", 
        "type": "Person"
      }, 
      {
        "familyName": "Piccoli", 
        "givenName": "David A.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-642-54053-0_14", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-642-54052-3", 
        "978-3-642-54053-0"
      ], 
      "name": "Pathology of Pediatric Gastrointestinal and Liver Disease", 
      "type": "Book"
    }, 
    "keywords": [
      "choice of therapy", 
      "treatment of hepatoblastoma", 
      "most hepatocellular carcinomas", 
      "small undifferentiated cells", 
      "aspects of histopathology", 
      "prognostic significance", 
      "rhabdoid variant", 
      "current regimens", 
      "surgical extirpation", 
      "infantile hemangiomas", 
      "hepatic tumors", 
      "histopathologic characterization", 
      "hepatocellular carcinoma", 
      "liver tumors", 
      "neoplastic cells", 
      "morphologic diagnosis", 
      "tumors", 
      "genetic abnormalities", 
      "diagnostic accuracy", 
      "therapy", 
      "current data", 
      "undifferentiated cells", 
      "gene expression", 
      "Hb", 
      "molecular genetic research", 
      "chemotherapy", 
      "cells", 
      "regimens", 
      "transplantation", 
      "prognosis", 
      "hepatoblastoma", 
      "neoplasms", 
      "propranolol", 
      "hemangioma", 
      "carcinoma", 
      "histopathology", 
      "abnormalities", 
      "liver", 
      "disease", 
      "diagnosis", 
      "carcinogenesis", 
      "childhood", 
      "treatment", 
      "children", 
      "rarity", 
      "presentation", 
      "toxicity", 
      "extirpation", 
      "international collaboration", 
      "genetic research", 
      "expression", 
      "pathway", 
      "advances", 
      "significance", 
      "variants", 
      "benefits", 
      "great progress", 
      "data", 
      "past quarter century", 
      "choice", 
      "progress", 
      "recognition", 
      "collaboration", 
      "outstanding issues", 
      "aspects", 
      "quarter century", 
      "research", 
      "insights", 
      "characterization", 
      "issues", 
      "chapter", 
      "accuracy", 
      "antecedents", 
      "disciplines", 
      "century"
    ], 
    "name": "Hepatic Tumors in Childhood", 
    "pagination": "547-614", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014905894"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-642-54053-0_14"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-642-54053-0_14", 
      "https://app.dimensions.ai/details/publication/pub.1014905894"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-12-01T06:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/chapter/chapter_266.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-3-642-54053-0_14"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-54053-0_14'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-54053-0_14'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-54053-0_14'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-54053-0_14'


 

This table displays all metadata directly associated to this object as RDF triples.

151 TRIPLES      22 PREDICATES      98 URIs      91 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-642-54053-0_14 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N7f5015c378c7450486702c04fc9a3cf1
4 schema:datePublished 2014-03-11
5 schema:datePublishedReg 2014-03-11
6 schema:description Great progress in the treatment of hepatoblastoma and some other tumors of the liver in children has been achieved in the past quarter century. Mostly, the benefits have derived from cis-platinum-based chemotherapy for neoplasms and propranolol for infantile hemangiomas. With the advances has come the recognition that thorough histopathologic characterization of HB has prognostic significance and should influence the choice of therapy. These advances have done less for disease that is all too often disseminated at presentation, including most hepatocellular carcinomas and the small undifferentiated cell and rhabdoid variants of HB. The rarity of the tumors has led to increasing international collaboration among all disciplines to address the outstanding issues. Molecular genetic research on pathways of gene expression is providing insights into carcinogenesis and will lead to therapies that avoid the toxicity of current regimens while more effectively attacking the neoplastic cells. But traditional morphologic diagnoses and complete surgical extirpation, including transplantation, remain essential. This chapter summarizes the current data on the antecedent and acquired genetic abnormalities in liver tumors while emphasizing those aspects of histopathology that are essential for diagnostic accuracy and prognosis.
7 schema:editor Na1cb681cab7c4326a070b6810b6df84f
8 schema:genre chapter
9 schema:isAccessibleForFree false
10 schema:isPartOf N467b9fe1e46549129a9ca63689c418a1
11 schema:keywords Hb
12 abnormalities
13 accuracy
14 advances
15 antecedents
16 aspects
17 aspects of histopathology
18 benefits
19 carcinogenesis
20 carcinoma
21 cells
22 century
23 chapter
24 characterization
25 chemotherapy
26 childhood
27 children
28 choice
29 choice of therapy
30 collaboration
31 current data
32 current regimens
33 data
34 diagnosis
35 diagnostic accuracy
36 disciplines
37 disease
38 expression
39 extirpation
40 gene expression
41 genetic abnormalities
42 genetic research
43 great progress
44 hemangioma
45 hepatic tumors
46 hepatoblastoma
47 hepatocellular carcinoma
48 histopathologic characterization
49 histopathology
50 infantile hemangiomas
51 insights
52 international collaboration
53 issues
54 liver
55 liver tumors
56 molecular genetic research
57 morphologic diagnosis
58 most hepatocellular carcinomas
59 neoplasms
60 neoplastic cells
61 outstanding issues
62 past quarter century
63 pathway
64 presentation
65 prognosis
66 prognostic significance
67 progress
68 propranolol
69 quarter century
70 rarity
71 recognition
72 regimens
73 research
74 rhabdoid variant
75 significance
76 small undifferentiated cells
77 surgical extirpation
78 therapy
79 toxicity
80 transplantation
81 treatment
82 treatment of hepatoblastoma
83 tumors
84 undifferentiated cells
85 variants
86 schema:name Hepatic Tumors in Childhood
87 schema:pagination 547-614
88 schema:productId N72465eb7702d44abb429dfa9c7fe7ad7
89 Na0a23226127d41dba45d19241df73fb8
90 schema:publisher N8a42b3c92e474b3fbb553ed0dab764e8
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014905894
92 https://doi.org/10.1007/978-3-642-54053-0_14
93 schema:sdDatePublished 2022-12-01T06:49
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N15bcdb4dd79b4dc38e692d5f23f350dd
96 schema:url https://doi.org/10.1007/978-3-642-54053-0_14
97 sgo:license sg:explorer/license/
98 sgo:sdDataset chapters
99 rdf:type schema:Chapter
100 N15bcdb4dd79b4dc38e692d5f23f350dd schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N33de553448cc4d699bae3e1ca45d26cb rdf:first N77a8f33252f94dd0a351e8a8e626e090
103 rdf:rest rdf:nil
104 N467b9fe1e46549129a9ca63689c418a1 schema:isbn 978-3-642-54052-3
105 978-3-642-54053-0
106 schema:name Pathology of Pediatric Gastrointestinal and Liver Disease
107 rdf:type schema:Book
108 N72465eb7702d44abb429dfa9c7fe7ad7 schema:name doi
109 schema:value 10.1007/978-3-642-54053-0_14
110 rdf:type schema:PropertyValue
111 N73685f30d5044c7ab4319cb715122eb4 schema:familyName Ruchelli
112 schema:givenName Eduardo D.
113 rdf:type schema:Person
114 N77a8f33252f94dd0a351e8a8e626e090 schema:familyName Piccoli
115 schema:givenName David A.
116 rdf:type schema:Person
117 N7c5a96c6a6ab4d069828d97389e84eb5 rdf:first sg:person.014633403267.66
118 rdf:rest rdf:nil
119 N7f5015c378c7450486702c04fc9a3cf1 rdf:first sg:person.014103516477.24
120 rdf:rest N7c5a96c6a6ab4d069828d97389e84eb5
121 N8a42b3c92e474b3fbb553ed0dab764e8 schema:name Springer Nature
122 rdf:type schema:Organisation
123 Na0a23226127d41dba45d19241df73fb8 schema:name dimensions_id
124 schema:value pub.1014905894
125 rdf:type schema:PropertyValue
126 Na1cb681cab7c4326a070b6810b6df84f rdf:first Nb822c69b1a794264ac68108dc57e31d2
127 rdf:rest Nf92814a4f11a4df48d11edbcab32e4ab
128 Nb822c69b1a794264ac68108dc57e31d2 schema:familyName Russo
129 schema:givenName Pierre
130 rdf:type schema:Person
131 Nf92814a4f11a4df48d11edbcab32e4ab rdf:first N73685f30d5044c7ab4319cb715122eb4
132 rdf:rest N33de553448cc4d699bae3e1ca45d26cb
133 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
134 schema:name Biological Sciences
135 rdf:type schema:DefinedTerm
136 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
137 schema:name Genetics
138 rdf:type schema:DefinedTerm
139 sg:person.014103516477.24 schema:affiliation grid-institutes:grid.39382.33
140 schema:familyName Finegold
141 schema:givenName Milton J.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014103516477.24
143 rdf:type schema:Person
144 sg:person.014633403267.66 schema:affiliation grid-institutes:grid.39382.33
145 schema:familyName López-Terrada
146 schema:givenName Dolores H.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014633403267.66
148 rdf:type schema:Person
149 grid-institutes:grid.39382.33 schema:alternateName Department of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA
150 schema:name Department of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA
151 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...