Identification of Cannabinoids and Metabolites in Biological Materials by Combined Gas-Liquid Chromatography—Mass Spectrometry View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1976

AUTHORS

Monroe E. Wall , Dolores R. Brine

ABSTRACT

Studies from several research groups have shown that Δ9-tetra-hydrocannabinol (Δ9-THC) and related cannabinoids, such as can-nabidiol and cannabinol, are extensively metabolized by liver microsomal enzymes (cf. Mechoulam [2] and Paton and Crown [3] for recent reviews). Studies from our laboratories have shown that the major metabolic route involves rapid hydroxylation at carbon 11 followed by further oxidation to the carboxylic acids [4–7]. Minor routes involve hydroxylation at the 8α or 8β positions, or in the side chain singly or in combination with the major routes. The sites of hydroxylation in the THC molecule are shown in Figure 5.1. More... »

PAGES

51-62

Book

TITLE

Marihuana

ISBN

978-3-642-51626-9
978-3-642-51624-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-51624-5_5

DOI

http://dx.doi.org/10.1007/978-3-642-51624-5_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041450827


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