A Comparison of the Subcellular Distribution of Cannabinoids in the Brains of Tolerant and Nontolerant Dogs, Rats, and Mice After ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1976

AUTHORS

William L. Dewey , Billy R. Martin , Jacqueline S. Beckner , Louis S. Harris

ABSTRACT

A number of papers have appeared which contain evidence that laboratory animals develop tolerance to many of the effects of Δ9-tetrahydrocannabinol (Δ9-THC). For example, previous work from this laboratory [5] has shown that dogs develop tolerance to the behavioral effects of Δ9-THC., the tolerance has a short onset, a long duration, and a large magnitude. A number of investigators have shown that rats develop tolerance to the behavioral effects of Δ9-THC [1,2,12]. Tolerance to the behavioral effeas of Δ9-THC in mice has been reported [16] but has not been confirmed or extended before this study. The results of many of these and other studies were considered in other review articles concerned with Δ9-THC tolerance in laboratory animals which were published from this laboratory [6,10,11]. Two of the review articles [10,11] were concerned primarily with characterizing the phenomenon of the tolerance observed in many laboratory species. The other review [6] contained the results of a number of studies in pigeons and dogs which were directed toward elucidating the mechanism or mechanisms responsible for the development of tolerance to this drug. More... »

PAGES

349-365

Book

TITLE

Marihuana

ISBN

978-3-642-51626-9
978-3-642-51624-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-51624-5_29

DOI

http://dx.doi.org/10.1007/978-3-642-51624-5_29

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050371682


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