Interleukin 10 and the Inflammatory Response View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

D. Rennick , S. Hudak , B. Hunt , G. Holland , D. Berg , K. Rajewski , R. Kuhn , W. Muller

ABSTRACT

A major advance in the study of immunity has been the identification of cytokines which mediate various aspects of acute and chronic inflammation. In vitro and in vivo studies have begun to elucidate the actions of cytokines and their importance in the generation, recruitment and effector function of different inflammatory and immune-reactive cells. In this regard, two types of helper T cells (designated Thl and Th2) were identified based on their cytokine production. These discrete cytokine patterns have been correlated to the ability of Thl cells to provide cell- mediated immunity and Th2 cells to provide superior help for humoral immunity. Th2 cell responses have also been linked to immediate hypersensitivity reactions (reviewed in Mosmann 1991). Because cellular and humoral immunity are mutually exclusive in certain disease states, evidence for cross regulation by Thl and Th2 cells was sought and found. IL-10 was identified as a Th2 product which inhibits Thl cytokine production (Fiorentino 1989; Moore 1990). More... »

PAGES

355-360

Book

TITLE

Progress in Immunology Vol. VIII

ISBN

978-3-642-51481-4
978-3-642-51479-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-51479-1_47

DOI

http://dx.doi.org/10.1007/978-3-642-51479-1_47

DIMENSIONS

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