Cytokine Production by Human Cells after Toxoplasma gondii Infection View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1996

AUTHORS

H. Pelloux , P. Ambroise-Thomas

ABSTRACT

Although the pathophysiology of toxoplasmosis is not fully understood, it is now clear that the cytokine network plays a major role in the cellular mechanisms involved in the control of Toxoplasma gondii infection (Beaman et al. 1992). This is of main importance in the central nervous system, where most of the clinical lesions are localised in case of congenital toxoplasmosis or in case of reactivations in immunocompromised patients (Hunter and Remington 1994). Most of the research works carried out up to now have focused on mouse models or have analyzed murine cells in vitro (Hunter and Remington 1994). Among these different studies, only some of them were devoted to cytokine production after T. gondii infection. Even fewer studies have analyzed the role of cytokines in human individuals or in human cell populations in vitro. In this review, we will attempt to summarize the different results obtained for cytokine secretion and/or expression after T. gondii infection in human models, both in vivo and in vitro. More... »

PAGES

155-163

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-51014-4_14

DOI

http://dx.doi.org/10.1007/978-3-642-51014-4_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012611026


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