Expression of the Homeobox Genes Hox 2.1 and 2.6 During Mouse Development View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

A. Graham , P. W. H. Holland , A. Lumsden , R. Krumlauf , B. L. M. Hogan

ABSTRACT

The homeobox is a conserved DNA sequence of about 183 nucleotides identified within a number of Drosophila genes which regulate certain aspects of early development. The homeobox sequence encodes a 61 amino acid homeodomain containing a helix-turn-helix motif which is probably involved in DNA binding. Drosophila genes containing a homeobox include some segmentation genes which are involved in generating a metameric pattern, and many homeotic genes (Gehring 1987). Homeotic genes have roles in establishing segment identity, which involves the specification of positional values along the anteroposterior body axis — a process which must occur in the embryos of all bilateral animals, not only those with a segmented body plan. It is therefore significant that several Drosophila homeobox-containing genes are expressed in patterns which suggest roles in positional specification independent of the process of segmentation (Doyle 1986; Hoey et al., 1986; Akam 1987; Gehring 1987). More... »

PAGES

87-93

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-50059-6_14

DOI

http://dx.doi.org/10.1007/978-3-642-50059-6_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024867589

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2901327


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