1998
AUTHORSA. Howell , E. Anderson , R. Blamey , R. B. Clarke , J. M. Dixon , M. Dowsett , S. R. D. Johnston , W. R. Miller , R. Nicholson , J. F. R. Robertson
ABSTRACTPrimary endocrine therapy is potentially superior to primary chemotherapy in patients with ER-positive tumors. The ability to give endocrine therapy perioperatively may be a better test than chemotherapy of the hypothesis that the events accompanying surgery affect prognosis. However, a major problem in all studies of primary endocrine therapy is that there has been no clear experimental test of preoperative versus postoperative therapy. This is because the major thrust of treatment has been in the elderly with the purpose of determining whether surgery can be avoided altogether. The fact that in ER-positive tumors primary endocrine therapy is associated with similar response rates to chemotherapy make it an attractive therapy for older women. This is the group where adjuvant chemotherapy has not been adequately tested (> or = 70 years of age). In contradistinction, adjuvant endocrine therapy shows marked survival benefits in patients with ER-positive tumors in these age groups (Table 1). It appears likely that primary endocrine therapy will allow breast conservation and prognostic information as is seen with chemotherapy. A major question which requires answering is whether primary endocrine therapy will improve survival more than adjuvant therapy alone. Although ER status is a good marker of responsiveness, its specificity, in particular, is not optimal. The ability to assess the dynamic effects of primary endocrine therapy by sequential biopsy and measurement of biological responses to oestrogen deprivation may allow us to predict precisely the patients likely to benefit from treatment. This clinical scenario allows us to use other potentially useful assessments such as the non-invasive estimation of angiogenesis using quantitative imaging techniques of blood flow. The newer anti-estrogens and aromatase inhibitors appear ideally suited to primary therapy since they have rapid and profound inhibitory activities, few or no agonist effects, and low side effect profiles. A preoperative trial of Faslodex is planned by the EORTC and another with Arimidex is under consideration by the ATAC (Arimidex, tamoxifen and combined) Trialist Group (Fig. 7). The precise design of these studies will require considerable thought. More... »
PAGES227-44
Adjuvant Therapy of Primary Breast Cancer VI
ISBN
978-3-642-45771-5
978-3-642-45769-2
http://scigraph.springernature.com/pub.10.1007/978-3-642-45769-2_22
DOIhttp://dx.doi.org/10.1007/978-3-642-45769-2_22
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1037992936
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/9928561
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents, Hormonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemotherapy, Adjuvant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Preoperative Care",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Randomized Controlled Trials as Topic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Estrogen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tamoxifen",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Christie Hospital NHS Foundation Trust",
"id": "https://www.grid.ac/institutes/grid.412917.8",
"name": [
"CRC Department of Medical Oncology and Department of Clinical Research, Christie Hospital NHS Trust, Manchester, M20 4BX, UK"
],
"type": "Organization"
},
"familyName": "Howell",
"givenName": "A.",
"id": "sg:person.01005610111.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005610111.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Christie Hospital NHS Foundation Trust",
"id": "https://www.grid.ac/institutes/grid.412917.8",
"name": [
"CRC Department of Medical Oncology and Department of Clinical Research, Christie Hospital NHS Trust, Manchester, M20 4BX, UK"
],
"type": "Organization"
},
"familyName": "Anderson",
"givenName": "E.",
"id": "sg:person.01017056053.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017056053.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nottingham City Hospital",
"id": "https://www.grid.ac/institutes/grid.412920.c",
"name": [
"Department of Surgery, Nottingham City Hospital, Nottingham, NG5 1PB, UK"
],
"type": "Organization"
},
"familyName": "Blamey",
"givenName": "R.",
"id": "sg:person.015650304144.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015650304144.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Christie Hospital NHS Foundation Trust",
"id": "https://www.grid.ac/institutes/grid.412917.8",
"name": [
"CRC Department of Medical Oncology and Department of Clinical Research, Christie Hospital NHS Trust, Manchester, M20 4BX, UK"
],
"type": "Organization"
},
"familyName": "Clarke",
"givenName": "R. B.",
"id": "sg:person.013322557500.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013322557500.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Western General Hospital",
"id": "https://www.grid.ac/institutes/grid.417068.c",
"name": [
"Edinburgh Breast Unit and ICRF Med Oncology Unit, Western General Hospital, Edinburgh, EH4 2XU, UK"
],
"type": "Organization"
},
"familyName": "Dixon",
"givenName": "J. M.",
"id": "sg:person.0726540700.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726540700.25"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Royal Marsden Hospital",
"id": "https://www.grid.ac/institutes/grid.424926.f",
"name": [
"Academic Department of Biochemistry, Royal Marsden Hospital, London, SW3 6JJ, UK"
],
"type": "Organization"
},
"familyName": "Dowsett",
"givenName": "M.",
"id": "sg:person.07405741202.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07405741202.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Royal Marsden Hospital",
"id": "https://www.grid.ac/institutes/grid.424926.f",
"name": [
"Academic Department of Biochemistry, Royal Marsden Hospital, London, SW3 6JJ, UK"
],
"type": "Organization"
},
"familyName": "Johnston",
"givenName": "S. R. D.",
"id": "sg:person.010537111522.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010537111522.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Western General Hospital",
"id": "https://www.grid.ac/institutes/grid.417068.c",
"name": [
"Edinburgh Breast Unit and ICRF Med Oncology Unit, Western General Hospital, Edinburgh, EH4 2XU, UK"
],
"type": "Organization"
},
"familyName": "Miller",
"givenName": "W. R.",
"id": "sg:person.0735237451.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735237451.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tenovus Cancer Care",
"id": "https://www.grid.ac/institutes/grid.453602.6",
"name": [
"Tenovus Institute of Cancer Research, Cardiff, CF4 4XX, UK"
],
"type": "Organization"
},
"familyName": "Nicholson",
"givenName": "R.",
"id": "sg:person.0670333460.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670333460.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nottingham City Hospital",
"id": "https://www.grid.ac/institutes/grid.412920.c",
"name": [
"Department of Surgery, Nottingham City Hospital, Nottingham, NG5 1PB, UK"
],
"type": "Organization"
},
"familyName": "Robertson",
"givenName": "J. F. R.",
"id": "sg:person.013163325712.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013163325712.61"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/bjc.1996.385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002002262",
"https://doi.org/10.1038/bjc.1996.385"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1996.385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002002262",
"https://doi.org/10.1038/bjc.1996.385"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archsurg.1989.01410050038006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002848620"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1989.122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005779164",
"https://doi.org/10.1038/bjc.1989.122"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1989.122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005779164",
"https://doi.org/10.1038/bjc.1989.122"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bjs.1800791224",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006108274"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmj.284.6319.869-a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007117267"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(97)00260-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010122317"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(89)92445-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011466455"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(89)92445-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011466455"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00666494",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012797309",
"https://doi.org/10.1007/bf00666494"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00666494",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012797309",
"https://doi.org/10.1007/bf00666494"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.89.10.4658",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017406983"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(197112)28:6<1479::aid-cncr2820280622>3.0.co;2-m",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021032825"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1996.129",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021090188",
"https://doi.org/10.1038/bjc.1996.129"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1996.129",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021090188",
"https://doi.org/10.1038/bjc.1996.129"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0959-8049(94)90161-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021209727"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1991.131",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025308790",
"https://doi.org/10.1038/bjc.1991.131"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1991.131",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025308790",
"https://doi.org/10.1038/bjc.1991.131"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-291x(87)90819-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025913155"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000227085",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026647677"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0959-8049(92)90148-u",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027172549"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01807034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027372323",
"https://doi.org/10.1007/bf01807034"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01807034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027372323",
"https://doi.org/10.1007/bf01807034"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(98)80043-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027407942"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jso.2930600203",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030376518"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0959-8049(94)00327-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030710472"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1005796915388",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033774096",
"https://doi.org/10.1023/a:1005796915388"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19930701)72:1<131::aid-cncr2820720125>3.0.co;2-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034393802"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bjs.1800780523",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037421235"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0959-8049(92)90146-s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038314772"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmj.290.6465.358",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042601354"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bjs.1800791225",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042814194"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1993.111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042923689",
"https://doi.org/10.1038/bjc.1993.111"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1993.111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042923689",
"https://doi.org/10.1038/bjc.1993.111"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1005835428423",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043959136",
"https://doi.org/10.1023/a:1005835428423"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0215(19970807)72:4<608::aid-ijc10>3.0.co;2-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050791804"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.2910590508",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051260168"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmj.314.7098.1843",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062780028"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmj.314.7098.1843",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062780028"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1259/0007-1285-55-655-511",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064554014"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077315729",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078973753",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079250639",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079953792",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080576805",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080947691",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081992673",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082219512",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082315630",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1995.13.3.537",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082550201"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082689799",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082734074",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082973254",
"type": "CreativeWork"
}
],
"datePublished": "1998",
"datePublishedReg": "1998-01-01",
"description": "Primary endocrine therapy is potentially superior to primary chemotherapy in patients with ER-positive tumors. The ability to give endocrine therapy perioperatively may be a better test than chemotherapy of the hypothesis that the events accompanying surgery affect prognosis. However, a major problem in all studies of primary endocrine therapy is that there has been no clear experimental test of preoperative versus postoperative therapy. This is because the major thrust of treatment has been in the elderly with the purpose of determining whether surgery can be avoided altogether. The fact that in ER-positive tumors primary endocrine therapy is associated with similar response rates to chemotherapy make it an attractive therapy for older women. This is the group where adjuvant chemotherapy has not been adequately tested (> or = 70 years of age). In contradistinction, adjuvant endocrine therapy shows marked survival benefits in patients with ER-positive tumors in these age groups (Table 1). It appears likely that primary endocrine therapy will allow breast conservation and prognostic information as is seen with chemotherapy. A major question which requires answering is whether primary endocrine therapy will improve survival more than adjuvant therapy alone. Although ER status is a good marker of responsiveness, its specificity, in particular, is not optimal. The ability to assess the dynamic effects of primary endocrine therapy by sequential biopsy and measurement of biological responses to oestrogen deprivation may allow us to predict precisely the patients likely to benefit from treatment. This clinical scenario allows us to use other potentially useful assessments such as the non-invasive estimation of angiogenesis using quantitative imaging techniques of blood flow. The newer anti-estrogens and aromatase inhibitors appear ideally suited to primary therapy since they have rapid and profound inhibitory activities, few or no agonist effects, and low side effect profiles. A preoperative trial of Faslodex is planned by the EORTC and another with Arimidex is under consideration by the ATAC (Arimidex, tamoxifen and combined) Trialist Group (Fig. 7). The precise design of these studies will require considerable thought.",
"editor": [
{
"familyName": "Senn",
"givenName": "Hans-J\u00f6rg",
"type": "Person"
},
{
"familyName": "Gelber",
"givenName": "Richard D.",
"type": "Person"
},
{
"familyName": "Goldhirsch",
"givenName": "Aron",
"type": "Person"
},
{
"familyName": "Th\u00fcrlimann",
"givenName": "Beat",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-3-642-45769-2_22",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-3-642-45771-5",
"978-3-642-45769-2"
],
"name": "Adjuvant Therapy of Primary Breast Cancer VI",
"type": "Book"
},
"name": "The Primary Use of Endocrine Therapies",
"pagination": "227-44",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-3-642-45769-2_22"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"b4fc6c05a5ffcb9262e2d967973c31df87f0584259deef850bba40382b485ae0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1037992936"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"9928561"
]
}
],
"publisher": {
"location": "Berlin, Heidelberg",
"name": "Springer Berlin Heidelberg",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-3-642-45769-2_22",
"https://app.dimensions.ai/details/publication/pub.1037992936"
],
"sdDataset": "chapters",
"sdDatePublished": "2019-04-15T21:03",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000266.jsonl",
"type": "Chapter",
"url": "http://link.springer.com/10.1007/978-3-642-45769-2_22"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-45769-2_22'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-45769-2_22'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-45769-2_22'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-45769-2_22'
This table displays all metadata directly associated to this object as RDF triples.
335 TRIPLES
23 PREDICATES
84 URIs
32 LITERALS
20 BLANK NODES