Biology of Germ Cell Tumors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Matthew Jonathan Murray , Stefan Schönberger

ABSTRACT

During the last decade key insights into the molecular basis of germ cell tumors (GCTs) have been elucidated. GCTs are believed to arise from primordial germ cells, which present similarities to embryonic stem cells in expression of pluripotency markers such as SALL4, LIN28 and EPCAM. The analysis of methylation, genomic imprinting, genomic aberrations and mRNA profiles clearly segregates pediatric from adult GCTs, while microRNA analysis revealed that overexpression of the oncogenic microRNA clusters miR-371~373 and miR-302 is common to both age groups. Furthermore, gene expression studies present distinct differences between the two commonest pediatric malignant histologic subtypes, namely germinomas and yolk sac tumors, with, for example, activation of the Wnt and BMP signaling pathway in the latter. This chapter summarizes the current state of research on GCTs arising in childhood and adulthood, identifying candidate biomarkers for diagnosis and follow-up and targets for the development of novel therapeutic agents for refractory or relapsed disease. More... »

PAGES

1-15

References to SciGraph publications

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  • Book

    TITLE

    Pediatric Germ Cell Tumors

    ISBN

    978-3-642-38970-2
    978-3-642-38971-9

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-642-38971-9_1

    DOI

    http://dx.doi.org/10.1007/978-3-642-38971-9_1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028058663


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