Renal Artery Denervation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014-02-26

AUTHORS

Thomas Zeller , Costas Tsioufis , Felix Mahfoud

ABSTRACT

Hypertension is highly prevalent and one of the most frequent chronic diseases worldwide. Approximately 10% of patients with high blood pressure are resistant to drug treatment in the presence of three or more antihypertensive drugs of different classes, including a diuretic, at maximal or the highest tolerated dose. Sympathetic overstimulation is one of the key components of resistant hypertension. Percutaneous catheter-based transluminal renal ablation (RDN) has emerged as a new approach to achieve sustained blood pressure reduction in patients with drug-resistant hypertension. Currently established radiofrequency- or ultrasound-based devices thermally damage the perivascular tissue of the renal artery interrupting the efferent and afferent sympathetic nerve bundles. Several position papers summarized the current evidence, unmet needs, and practical recommendations for the application of this therapeutic strategy in clinical practice. Given that there is no established intra-procedural control of ablation success, interventionalists have to be familiar with the aspects related to the anatomy and imaging of the renal arteries, the distribution of renal sympathetic fibers, the special equipment necessary for RDN, and the procedural details in order to maximize the success and minimize potential complications. This chapter summarizes the clinical background of essential hypertension, in particular resistant hypertension, currently published or presented data, and technical aspects of renal denervation. In 2013, commercially available (CE marked) renal denervation devices are described in detail. More... »

PAGES

1-35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-37393-0_125-1

DOI

http://dx.doi.org/10.1007/978-3-642-37393-0_125-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001455739


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