Antiplatelet Drugs in the Management of Cardiovascular Indications View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Jawed Fareed , Daneyal Syed , Omer Iqbal

ABSTRACT

Platelets play an integral role in primary hemostasis and in coronary atherothrombosis. Drugs such as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDS), vitamin E, and COX-2 inhibitors such as celecoxib (Celebrex) affect platelet function. Antiplatelet drugs such as ticlopidine, clopidogrel, prasugrel, ticagrelor, cangrelor, and elinogrel inhibit the adenosine diphosphate receptors on the platelet surface. Other antiplatelet drugs such as abciximab, eptifibatide, and tirofiban, by inhibiting the glycoprotein IIb/IIIa receptors, inhibit the final common pathway of platelet aggregation. Vorapaxar and atopaxar inhibit PAR1 thrombin receptor-activating peptide (TRAP)-induced platelet aggregation. Given the several agonists involved in different pathways of platelet aggregation, the combination of two antiplatelet drugs may be quite a rational approach in order to boost antithrombotic efficacy. Caution is needed in selecting the types of antiplatelet drugs as a combination therapy and their respective dosages in order to avoid serious bleeding complications. Several tests for monitoring antiplatelet drugs are available. The search for an ideal antiplatelet drug and also an ideal test for monitoring its effects continue. More... »

PAGES

953-973

References to SciGraph publications

Book

TITLE

PanVascular Medicine

ISBN

978-3-642-37077-9
978-3-642-37078-6

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-37078-6_218

DOI

http://dx.doi.org/10.1007/978-3-642-37078-6_218

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041938951


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