Induction of Neural Lineages from Mesoderm and Endoderm by Defined Transcription Factors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Marius Wernig

ABSTRACT

A major interest in developmental biology is the lineage plasticity of specialized cells. We recently generated induced neuronal (iN) cells from fibroblasts and hepatocytes by expression of defined pan-neuronal transcription factors. Moreover, we were able to generate induced neural precursor (iNP) cells following a similar transcription factor-based strategy, suggesting that cell fate plasticity is much wider than previously anticipated. Further studies showed that addition of subtype-specific regulators was sufficient to induce characteristic neuronal subtypes such as dopamine and motor neurons. Here, we review the most recent developments of our own research efforts as well as the relevant findings in the field as they pertain to direct induction of neural lineages. The derivation of neuronal cells from patient fibroblasts holds great promise to uncover human neurological disease mechanisms and to provide a donor source for autologous therapeutic transplantation. Similar to induced pluripotent stem (iPS) cells, much has yet to be learned about iN cells before clinical translation can be realized. More... »

PAGES

17-30

References to SciGraph publications

Book

TITLE

Programmed Cells from Basic Neuroscience to Therapy

ISBN

978-3-642-36647-5
978-3-642-36648-2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-36648-2_3

DOI

http://dx.doi.org/10.1007/978-3-642-36648-2_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016438886


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51 schema:description A major interest in developmental biology is the lineage plasticity of specialized cells. We recently generated induced neuronal (iN) cells from fibroblasts and hepatocytes by expression of defined pan-neuronal transcription factors. Moreover, we were able to generate induced neural precursor (iNP) cells following a similar transcription factor-based strategy, suggesting that cell fate plasticity is much wider than previously anticipated. Further studies showed that addition of subtype-specific regulators was sufficient to induce characteristic neuronal subtypes such as dopamine and motor neurons. Here, we review the most recent developments of our own research efforts as well as the relevant findings in the field as they pertain to direct induction of neural lineages. The derivation of neuronal cells from patient fibroblasts holds great promise to uncover human neurological disease mechanisms and to provide a donor source for autologous therapeutic transplantation. Similar to induced pluripotent stem (iPS) cells, much has yet to be learned about iN cells before clinical translation can be realized.
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