Drug Release Evaluation of Mesoporous TiO2: A Nano Carrier for Duloxetine View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Mani Ganesh , Pushparaj Hemalatha , Mei Mei Peng , Wang Seog Cha , Muthiahpillai Palanichamy , Hyun Tae Jang

ABSTRACT

Mesoporous TiO2 was synthesized solvothermally, but its XRD pattern proved little randomly arranged mesopores. Its DRS-UV-Vis spectrum showed characteristic band gap excitation just below 400 nm and oxygen to metal charge transfer close to 250 nm. It was loaded with the model drug duloxetine (DX) by wet method. Locked-in drug within the mesopores of TiO2 was confirmed by XRD, DRS-UV-Vis and FT-IR techniques. About 11% loading of drug was verified by UV-Vis spectroscopy. The study of drug release showed two stages of burst release between 0 and 12 h and beyond that slow extended release of DX occurred. The total burst release was equal to 20%, and even at the end of 40 h the total release was equal to 90%. Hence, mesoporous TiO2 was established as a viable, biocompatible DX reservoir for its controlled release. The same mesoporous TiO2 could be convenient for the release of potentially toxic drugs which require small and extended dose. More... »

PAGES

237-243

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-35248-5_33

DOI

http://dx.doi.org/10.1007/978-3-642-35248-5_33

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004980306


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