Novel Concepts of “Niche-Relief” and “Niche-Voltage” for Stem Cells as a Base of Bone and Hematopoietic Tissues Biomimetic Engineering View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

I. A. Khlusov , Yu. Dekhtyar , M. Yu. Khlusova , E. A. Gostischev , Yu. P. Sharkeev , V. F. Pichugin , E. V. Legostaeva

ABSTRACT

An affect of relief features and quantitative variables of artificial surfaces on structural-functional status of human lung prenatal stromal cells (HLPSC) and remodeling of Balb/c mice bone/bone marrow system have been studied. Implants with rough (Ra>2 μm) calcium phosphate micro-arc coatings have structural-functional sites (micro-regions) named “niches-relief” which are necessary for maturation and differentiation of HLPSC into secreting osteoblasts in shortterm culture. Maximal remodeling of mouse bone/bone marrow system in 45-day subcutaneous heterotopic test in vivo is also noted under optimal parameter (average index of cellular alkaline phosphatase area to artificial micro-region area is about 43 %) of osteogenic niche in vitro. Probable physical mechanism of osteogenic niche functioning has been determined. It correlates with increasing of electron work function supplied with a negative charge of calcium phosphate nanorelief in the sockets (artificial “niches”). “Niche-voltage” concept for bone tissue biomimetic engineering was proposed. More... »

PAGES

99-102

Book

TITLE

International Symposium on Biomedical Engineering and Medical Physics, 10-12 October, 2012, Riga, Latvia

ISBN

978-3-642-34196-0
978-3-642-34197-7

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-34197-7_26

DOI

http://dx.doi.org/10.1007/978-3-642-34197-7_26

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023711701


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