MORPH-PRO: A Novel Algorithm and Web Server for Protein Morphing View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2012

AUTHORS

Natalie E. Castellana , Andrey Lushnikov , Piotr Rotkiewicz , Natasha Sefcovic , Pavel A. Pevzner , Adam Godzik , Kira Vyatkina

ABSTRACT

Proteins are known to be dynamic in nature, changing from one conformation to another while performing vital cellular tasks. It is important to understand these movements in order to better understand protein function. At the same time, experimental techniques provide us with only single snapshots of the whole ensemble of available conformations. Computational protein morphing provides a visualization of a protein structure transitioning from one conformation to another by producing a series of intermediate conformations. We present a novel, efficient morphing algorithm, Morph-Pro based on linear interpolation. We also show that apart from visualization, morphing can be used to provide plausible intermediate structures. We test intermediate structures constructed by our algorithm for a protein kinase and evaluate these structures in a virtual docking experiment. The structures are shown to dock with higher score to known ligands than structures solved using X-Ray crystallography. More... »

PAGES

262-273

References to SciGraph publications

  • 1994-05. How does a protein fold? in NATURE
  • 2003-07. Implications of protein flexibility for drug discovery in NATURE REVIEWS DRUG DISCOVERY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/978-3-642-33122-0_21

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    DIMENSIONS

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