RNA Folding Algorithms with G-Quadruplexes View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2012

AUTHORS

Ronny Lorenz , Stephan H. Bernhart , Fabian Externbrink , Jing Qin , Christian Höner zu Siederdissen , Fabian Amman , Ivo L. Hofacker , Peter F. Stadler

ABSTRACT

G-quadruplexes are abundant locally stable structural elements in nucleic acids. The combinatorial theory of RNA structures and the dynamic programming algorithms for RNA secondary structure prediction are extended here to incorporate G-quadruplexes using a simple but plausible energy model. With preliminary energy parameters we find that the overwhelming majority of putative quadruplex-forming sequences in the human genome are likely to fold into canonical secondary structures instead. More... »

PAGES

49-60

References to SciGraph publications

Book

TITLE

Advances in Bioinformatics and Computational Biology

ISBN

978-3-642-31926-6
978-3-642-31927-3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-31927-3_5

DOI

http://dx.doi.org/10.1007/978-3-642-31927-3_5

DIMENSIONS

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