Hypoxia Imaging Agents Labeled with Positron Emitters View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012-08-24

AUTHORS

Lathika Hoigebazar , Jae Min Jeong

ABSTRACT

Imaging hypoxia using positron emission tomography (PET) is of great importance for therapy of cancer. [18F]Fluoromisonidazole (FMISO) was the first PET agent for hypoxia imaging, and various radiolabeled nitroimidazole derivatives such as [18F]fluoroerythronitroimidazole (FETNIM), [18F]1-α-d-(2-deoxy-2-fluoroarabinofuranosyl)-2-nitroimidazole (FAZA), [18F]2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide (EF-5), and [18F]fluoroetanidazole (FETA) have been developed successively. To overcome the high cost of cyclotron installation, 68Ga-labeled nitroimidazole derivatives also have been developed. Another important hypoxia imaging agent is 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu-ATSM), which can distribute in cancer tissue rapidly due to high lipophilicity. However, its application is limited due to high cost of radionuclide production. Although various hypoxia imaging agents have been reported and tested, hypoxia PET images still have to be improved, because of the low blood flow in hypoxic tissues and resulting low uptake of the agents. More... »

PAGES

285-299

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-27994-2_15

DOI

http://dx.doi.org/10.1007/978-3-642-27994-2_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025042297

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22918765


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