Nucleic Acids as Therapeutics View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Saraswat Pushpendra , Pareek Arvind , Bhandari Anil

ABSTRACT

Gene therapy is a technique for correcting defective genes responsible for disease development. Nucleic acid-based molecules (deoxyribonucleic acid, complementary deoxyribonucleic acid, complete genes, ribonucleic acid, and oligonucleotides) are utilized as research tools within the broad borders of gene therapy and the emerging field of molecular medicine. Although most of the nucleic acid-based drugs are in early stages of clinical trials, these classes of compounds have emerged in recent years to yield extremely promising candidates for drug therapy to a wide range of diseases, including cancer, infectious diseases, diabetes, cardiovascular, inflammatory, and neurodegenerative diseases, cystic fibrosis, hemophilia, and other genetic disorders. Gene therapy may be classified into two types: somatic and germ line gene therapy. There are many ethical, social, and commercial issues raised by the prospects of treating patients using gene therapy. This chapter summarizes deoxyribonucleic acid-based therapeutics, ribonucleic acid-based therapeutics, and gene transfer technologies. Deoxyribonucleic acid-based therapeutics includes plasmids, oligonucleotides for antisense and antigene applications, deoxyribonucleic acid aptamers, and deoxyribonucleic acidzymes, while ribonucleic acid-based therapeutics includes ribonucleic acid aptamers, ribonucleic acid decoys, antisense ribonucleic acid, ribozymes, small interfering ribonucleic acid, and micro ribonucleic acid. This chapter also includes current status of gene therapy and recent developments in gene therapy research. More... »

PAGES

19-45

Book

TITLE

From Nucleic Acids Sequences to Molecular Medicine

ISBN

978-3-642-27425-1
978-3-642-27426-8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-27426-8_2

DOI

http://dx.doi.org/10.1007/978-3-642-27426-8_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048257835


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