Tacrolimus hemmt die dermale, nicht jedoch die intestinale Wundheilung View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2003

AUTHORS

Michael Schäffer , N. Fuchs , J. Völker , R. Viebahn

ABSTRACT

Tacrolimus, used in solid organ transplantation, inhibits T-cell activation. Little is known about its effect on the immunoregulation of dermal and intestinal healing. In rats, the effect of tacrolimus (1–5 mg/kg/d) on dermal and left colonic healing was tested 10 days and 5 days post-wounding, respectively. Tacrolimus impaired dermal but not intestinal healing. Impaired healing was reflected in decreased levels of TGF-β (stimulates healing) and increased levels of IFN-γ and TNF-α (both impair healing) in wound fluid. More... »

PAGES

225-227

References to SciGraph publications

  • 1999-08. Immunregulation der Wundheilung in DER CHIRURG
  • Book

    TITLE

    Chirurgisches Forum 2003 für experimentelle und klinische Forschung

    ISBN

    978-3-540-00659-6
    978-3-642-19024-7

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-642-19024-7_63

    DOI

    http://dx.doi.org/10.1007/978-3-642-19024-7_63

    DIMENSIONS

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