Möglichkeit der Pouchitis-Therapie durch Interleukin-10 im ileoanalen Pouch nach Colitis ulcerosa? View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2003

AUTHORS

Anton J. Kroesen , T. Giese , S. Dullat , H. J. Buhr

ABSTRACT

Apart of the immunological reaction pouchitis shows many similarities to ulcerative colitis. Concerning the cytokine expression it is well known that during pouchitis the proinflammatory interleukines IL 1-β, IL-8, and TNF-α are upregulated whereas the counterinflammatory interleukine IL-10 is downregulated. The aim of this study was to identify in the long lasting intact ileoanal pouch cytokines which could have an protective effect or could lead to a new therapeutic option. MethodsSpecimens of each 10 were obtained endoscopically from the statuses: pre ileoanal pouch, pre closure of ileostomy, pouch 1 year in function, pouchitis, and controls. IL-6 and TNF-α as proinflammatory and IL-10 as counter inflammatory cytokines were determined. Specimens were conserved at −80 °C. After PCR amplification the DNA concentration was measured and after further dilution the amplification served as a standard under the use of hybridisation probes. After RNA isolation and transcription into cDNA further quantification was performed against GAPDH via realtime-PCR. ResultsIL-6 was reduced in the status of the intact pouch 1 year compared to intact pouch Conclusion1. Upregulation of IL-6 or TNF-α during pouchitis could not be observed. 2. Increased IL-10 in the mature pouch might be protective against pouchitis. 3. Topical IL-10 therapy could be a new issue for pouchitis treatment. More... »

PAGES

187-189

References to SciGraph publications

Book

TITLE

Chirurgisches Forum 2003 für experimentelle und klinische Forschung

ISBN

978-3-540-00659-6
978-3-642-19024-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-19024-7_52

DOI

http://dx.doi.org/10.1007/978-3-642-19024-7_52

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012408813


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