Stem Cell Infidelity View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2004

AUTHORS

Jonas Frisén

ABSTRACT

Cells differentiate according to stereotype pedigrees, or at least so we thought. Several studies have challenged this dogma, suggesting that stem cells in several tissues may be plastic and switch lineages, but many of the results are open to other interpretations. Is there solid evidence for stem cell plasticity and should we rewrite the textbooks just yet? Distinct lineages emerge from pluripotent cells during the succession of early embryogenesis, and progressively more restricted cells give rise to the specialized cells of differenct organs and tissues. Decades of developmental studies have provided us with a family tree fro the generation of the major classes of cells in the body, which has unveiled robust, stereotype pedigrees. It has been thought that celss only progress in one direction along these differentiation pathways and are unable to switch tracks. In many tissues, self-renewing multipotent stem cells are maintained in adulthood and serve either to replace cells that have a limited life span or to regenerate cells after injury. Such stem cells were believed to be restricted in their potential and limited to generating the types of cells present in the tissue in which the stem cells resided. For example, a neural stem cell would be restricted to generating neural cells and an epidermal stem cell to making skin cells. A flurry of studies over the last few year has challenged this concept, suggesting that certain tissue stem cells in embryos and adults may be more plastic than previously thought and may give rise to cells of unrelated lineages if transferred to another environment. In this new environment the stem cell would be able to respond to the novel instructive cues, which would reprogram the cell to generate cells appropriate for the new environment. This concept is known as stem cell plasticity. However, several recent studies have, suggested alternative explanations for some of the findings ascribed to stem cell plasticity, and they have questioned the existence of this event. When studying these processes, there are numerous caveats that pose a serious risk of errouneously interpreting these findings as signs of stem cell plasticity. It is important to unravel the potential extent and molecular biology of stem cell plasticity for several reasons. First, this concept challenges our view of how cellular differentiation is regulated. Second, it poses the question whether this process maybe in effect during normal physiological conditions and in pathological situations. Third, stem cells may offer an attractive source of cells for transplatation, and the concept of stem cell plasticity implies that certain adult stem cells may be much more potent and versatile than previously thought. Ultimately, they could offer an ethically uncontroversial and autologous alternative to embryonic stem cells in therapeutic situations. More... »

PAGES

95-107

Book

TITLE

Stem Cells in the Nervous System: Functional and Clinical Implications

ISBN

978-3-642-62339-4
978-3-642-18883-1

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-18883-1_7

DOI

http://dx.doi.org/10.1007/978-3-642-18883-1_7

DIMENSIONS

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