Cooperation Between Proteolysis and Endocytosis in Collagen Turnover View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2011-03-19

AUTHORS

Thomas H. Bugge , Niels Behrendt

ABSTRACT

Studies conducted as of today collectively suggest that the degradation of collagen in mammals is carried out in equal parts within the extracellular environment, via the action of a limited number of secreted or plasma membrane proteases with the unique ability to cleave native collagen, and intracellularly, via an assortment of lysosomal cathepsins that degrade collagen made available through its uptake by specific collagen endocytic receptors. Emerging evidence indicates that these two principal mechanisms for collagen degradation cooperate to form a single pathway that executes the sequential and complete degradation of collagen during both physiological tissue remodeling and pathological remodeling, including tumor progression. The chapter summarizes the prevailing paradigms regarding the turnover of this abundant extracellular matrix molecule. More... »

PAGES

53-74

Book

TITLE

Extracellular Matrix Degradation

ISBN

978-3-642-16860-4
978-3-642-16861-1

From Grant

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-16861-1_3

DOI

http://dx.doi.org/10.1007/978-3-642-16861-1_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022141748


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