How Type of Malignancy and Treatment Assist in the Etiological Diagnosis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010-12-22

AUTHORS

Alexandre Boyer , Didier Gruson

ABSTRACT

The type of immune deficiency affects the risk of specific pulmonary complications. The risk of infection is particularly high when neutropenia develops and is chiefly associated with infections by extracellular pyogenic bacteria and fungi. B-lymphocyte dysfunction due to chemotherapy or lymphoproliferative disorders is associated with bacterial infections, especially due pyogenic bacteria. Impaired cellular immunity, with T-lymphocyte dysfunction or steroid therapy, is associated with intracellular bacteria, viral and fungal infections, for example, due to Pneumocystis jirovecii. The best example for the relation between specific immune deficiency and infection is the well-known three time periods, defined after allogeneic stem-cell transplantation. Severe specific immune dysfunction is present during each period following stem-cell transplantation. Furthermore, in this context, the activation of the inflammatory cascades and T-cell alloreactivity explain the occurrence of many non-infectious complications.To know the specific cause of immune dysfunction could help in the reasoning for the best diagnostic method and for the choice of an empirical infectious treatment. More... »

PAGES

123-129

Book

TITLE

Pulmonary Involvement in Patients with Hematological Malignancies

ISBN

978-3-642-15741-7
978-3-642-15742-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-15742-4_11

DOI

http://dx.doi.org/10.1007/978-3-642-15742-4_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047467656


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