Endokrine Tumoren des gastroenteropankreatischen Systems View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

R. Arnold , P. Langer , Matthias Rothmund , G. Klöppel , P.H. Kann , J.T. Heverhagen , V. Fendrich , D.K. Bartsch , A. Rinke , X. Müller , K.J. Klose , W. Brenner , V. Prasad , B. Wiedenmann , H. Jann , T. Gress , A. Pascher , P. Neuhaus , N. Habbe , B. Simon , B. Stinner

ABSTRACT

Das endokrine gastroenteropankreatoische System ist das größte endokrine System des Körpers. Die hier gebildeten Hormone sind für die Freisetzung von Verdauungssäften, die Darmmotilität und die Trophik verantwortlich. In gleicher Weise ist aber auch das enterische Nervensystem in diese Aufgaben involviert. Der einzige bekannte klinisch relevante Mangelzustand ist der Diabetes mellitus Typ 1, bedingt durch den Ausfall der pankreatischen β-Zelle. In der Pathogenese des Diabetes mellitus Typ 2 spielt eine herabgesetzte Sekretion des Inkretinhormons GLP-1 eine wichtige Rolle. Exogene Verabfolgung von GLP-1-Analoga verbessert die Stoffwechselsituation und steht heute therapeutisch zur Verfügung. Beispiele einer autonomen Hypersekretion sind endokrine Tumoren. More... »

PAGES

497-628

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-14285-7_5

DOI

http://dx.doi.org/10.1007/978-3-642-14285-7_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024081837


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646 schema:description Das endokrine gastroenteropankreatoische System ist das größte endokrine System des Körpers. Die hier gebildeten Hormone sind für die Freisetzung von Verdauungssäften, die Darmmotilität und die Trophik verantwortlich. In gleicher Weise ist aber auch das enterische Nervensystem in diese Aufgaben involviert. Der einzige bekannte klinisch relevante Mangelzustand ist der Diabetes mellitus Typ 1, bedingt durch den Ausfall der pankreatischen β-Zelle. In der Pathogenese des Diabetes mellitus Typ 2 spielt eine herabgesetzte Sekretion des Inkretinhormons GLP-1 eine wichtige Rolle. Exogene Verabfolgung von GLP-1-Analoga verbessert die Stoffwechselsituation und steht heute therapeutisch zur Verfügung. Beispiele einer autonomen Hypersekretion sind endokrine Tumoren.
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