Reconstructing Histories of Complex Gene Clusters on a Phylogeny View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009

AUTHORS

Tomáš Vinař , Broňa Brejová , Giltae Song , Adam Siepel

ABSTRACT

Clusters of genes that have evolved by repeated segmental duplication present difficult challenges throughout genomic analysis, from sequence assembly to functional analysis. These clusters are one of the major sources of evolutionary innovation, and they are linked to multiple diseases, including HIV and a variety of cancers. Understanding their evolutionary histories is a key to the application of comparative genomics methods in these regions of the genome. We propose a probabilistic model of gene cluster evolution on a phylogeny, and an MCMC algorithm for reconstruction of duplication histories from genomic sequences in multiple species. Several projects are underway to obtain high quality BAC-based assemblies of duplicated clusters in multiple species, and we anticipate use of our methods in their analysis. Supplementary materials are located at http://compbio.fmph.uniba.sk/suppl/09recombcg/ More... »

PAGES

150-163

Book

TITLE

Comparative Genomics

ISBN

978-3-642-04743-5
978-3-642-04744-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-04744-2_13

DOI

http://dx.doi.org/10.1007/978-3-642-04744-2_13

DIMENSIONS

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