Adverse Drug Reactions Affecting Blood Cells View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010

AUTHORS

Richard H. Aster

ABSTRACT

Numerous medications and other xenobiotics are capable of producing adverse reactions (ADRs) affecting red cells, platelets or neutrophils. Occasionally, more than one blood element is affected simultaneously. As with all drug reactions, some side effects are a direct consequence of a known pharmacologic action of the drug and are dose-dependent; others occur sporadically and relatively independent of dose. The latter ("idiosyncratic") reactions are unpredictable and, in general, have no known underlying genetic basis. Many are antibody-mediated, as would be expected since cellular immune effector cells have little direct access to circulating blood cells. In this chapter, we will discuss idiosyncratic drug reactions affecting blood and blood forming tissues with an emphasis on those thought to be immune-mediated. More... »

PAGES

57-76

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-00663-0_3

DOI

http://dx.doi.org/10.1007/978-3-642-00663-0_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048690557

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20020259


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anemia, Aplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Platelets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug-Related Side Effects and Adverse Reactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Environmental Pollutants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Erythrocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematologic Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutrophils", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Bloodcenter of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.280427.b", 
          "name": [
            "Blood Research Institute, Blood Center of Wisconsin, 2178 Watertown Plank Rd, Milwaukee, 53201, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aster", 
        "givenName": "Richard H.", 
        "id": "sg:person.015510362157.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015510362157.72"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0755-4982(04)98884-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000039512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1993.tb03070.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002889538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci110710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004799896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0404201101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004832467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.12020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005655843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminhematol.2005.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005842429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0953-6205(02)00085-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007034376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0953-6205(02)00085-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007034376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e3282fa7470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007863510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e3282fa7470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007863510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.10331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008035352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1986.tb04130.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008686684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.97.17.1680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010066561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v99.6.2054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013354856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.164.2.218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013420627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1537-2995.2000.40060663.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014188860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci112901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016459002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.12855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016498048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci111691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020217781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0887-7963(93)70144-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020385171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.20516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021574335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.20516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021574335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1991.tb08624.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024449102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0037-1963(00)90101-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025052028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejim.2006.07.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026512583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hoc.2007.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027300792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0887-7963(93)70142-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027647599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2004.00744.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027766803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e3282f15fb9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028182276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e3282f15fb9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028182276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1537-2995.1990.30891020326.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028355857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.20490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030458022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.20490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030458022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0049-0172(87)90006-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032947584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0049-0172(87)90006-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032947584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-12-063941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033660809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1537-2995.1994.341195065037.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037410831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra066469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039578506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1054/mehy.1998.0734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040493147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1537-2995.1984.24384225022.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041557497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pds.1542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041992880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.12.3846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046021090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198508223130803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047681361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1526-0968.2003.00127.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048984191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-01-009803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049008460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1537-2995.2007.01173.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049944359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0887-7963(93)70145-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053577207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2004-831039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057437129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-108-2-206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073692427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-135-12-200112180-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073704955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-139-3-200308050-00021-w4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073706468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-143-10-200511150-00028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073708178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-146-9-200705010-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073709281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-60-3-506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073722496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.58.1.207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074656334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075114469", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075853296", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076860435", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077609539", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077806545", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079456767", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079556962", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082343223", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083111457", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010", 
    "datePublishedReg": "2010-01-01", 
    "description": "Numerous medications and other xenobiotics are capable of producing adverse reactions (ADRs) affecting red cells, platelets or neutrophils. Occasionally, more than one blood element is affected simultaneously. As with all drug reactions, some side effects are a direct consequence of a known pharmacologic action of the drug and are dose-dependent; others occur sporadically and relatively independent of dose. The latter (\"idiosyncratic\") reactions are unpredictable and, in general, have no known underlying genetic basis. Many are antibody-mediated, as would be expected since cellular immune effector cells have little direct access to circulating blood cells. In this chapter, we will discuss idiosyncratic drug reactions affecting blood and blood forming tissues with an emphasis on those thought to be immune-mediated.", 
    "editor": [
      {
        "familyName": "Uetrecht", 
        "givenName": "Jack", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-642-00663-0_3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2529602", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": {
      "isbn": [
        "978-3-642-00662-3", 
        "978-3-642-00663-0"
      ], 
      "name": "Adverse Drug Reactions", 
      "type": "Book"
    }, 
    "name": "Adverse Drug Reactions Affecting Blood Cells", 
    "pagination": "57-76", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-642-00663-0_3"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e7f3fe2d22243ba9667c217b32ce8e07a5d74656238da9cf392f8985cf9f96f7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048690557"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20020259"
        ]
      }
    ], 
    "publisher": {
      "location": "Berlin, Heidelberg", 
      "name": "Springer Berlin Heidelberg", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-642-00663-0_3", 
      "https://app.dimensions.ai/details/publication/pub.1048690557"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T17:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000273.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-3-642-00663-0_3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-00663-0_3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-00663-0_3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-00663-0_3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-00663-0_3'


 

This table displays all metadata directly associated to this object as RDF triples.

276 TRIPLES      23 PREDICATES      96 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-642-00663-0_3 schema:about N0e7c9e1d05b340bda97669416c41a5a2
2 N10fa9301b5d547adb4f93eaa300bf7d9
3 N14ce2fb768c145c7b6bbcbbc71047777
4 N48bec2778ef14d0a9bc6b62c7957f2b8
5 N54a550b53af04c278916dbc705563e3a
6 N62e3add3ad6c428dbff46b5b6d72b08a
7 N66f63e03343a4a9db20f15a5d104d91d
8 N6deaf61026ac4829a0d4750ec032477a
9 Nbd8ce799d4a041c295161ee1e0186513
10 Nd099281cceed4551a1e551d0931011e9
11 anzsrc-for:11
12 anzsrc-for:1107
13 schema:author N2d0cb1421fec483088822216230c95df
14 schema:citation https://app.dimensions.ai/details/publication/pub.1075114469
15 https://app.dimensions.ai/details/publication/pub.1075853296
16 https://app.dimensions.ai/details/publication/pub.1076860435
17 https://app.dimensions.ai/details/publication/pub.1077609539
18 https://app.dimensions.ai/details/publication/pub.1077806545
19 https://app.dimensions.ai/details/publication/pub.1079456767
20 https://app.dimensions.ai/details/publication/pub.1079556962
21 https://app.dimensions.ai/details/publication/pub.1082343223
22 https://app.dimensions.ai/details/publication/pub.1083111457
23 https://doi.org/10.1001/archinte.164.2.218
24 https://doi.org/10.1002/ajh.10331
25 https://doi.org/10.1002/ajh.20490
26 https://doi.org/10.1002/ajh.20516
27 https://doi.org/10.1002/pds.1542
28 https://doi.org/10.1016/0049-0172(87)90006-0
29 https://doi.org/10.1016/j.ejim.2006.07.012
30 https://doi.org/10.1016/j.hoc.2007.06.004
31 https://doi.org/10.1016/s0037-1963(00)90101-x
32 https://doi.org/10.1016/s0755-4982(04)98884-7
33 https://doi.org/10.1016/s0887-7963(93)70142-x
34 https://doi.org/10.1016/s0887-7963(93)70144-3
35 https://doi.org/10.1016/s0887-7963(93)70145-5
36 https://doi.org/10.1016/s0953-6205(02)00085-7
37 https://doi.org/10.1046/j.1537-2995.1984.24384225022.x
38 https://doi.org/10.1046/j.1537-2995.1990.30891020326.x
39 https://doi.org/10.1046/j.1537-2995.1994.341195065037.x
40 https://doi.org/10.1046/j.1537-2995.2000.40060663.x
41 https://doi.org/10.1053/j.seminhematol.2005.04.004
42 https://doi.org/10.1054/mehy.1998.0734
43 https://doi.org/10.1055/s-2004-831039
44 https://doi.org/10.1056/nejm198508223130803
45 https://doi.org/10.1056/nejmra066469
46 https://doi.org/10.1073/pnas.0404201101
47 https://doi.org/10.1097/moh.0b013e3282f15fb9
48 https://doi.org/10.1097/moh.0b013e3282fa7470
49 https://doi.org/10.1111/j.1365-2141.1986.tb04130.x
50 https://doi.org/10.1111/j.1365-2141.1991.tb08624.x
51 https://doi.org/10.1111/j.1365-2141.1993.tb03070.x
52 https://doi.org/10.1111/j.1526-0968.2003.00127.x
53 https://doi.org/10.1111/j.1537-2995.2007.01173.x
54 https://doi.org/10.1111/j.1538-7836.2004.00744.x
55 https://doi.org/10.1124/mol.58.1.207
56 https://doi.org/10.1161/01.cir.97.17.1680
57 https://doi.org/10.1172/jci110710
58 https://doi.org/10.1172/jci111691
59 https://doi.org/10.1172/jci112901
60 https://doi.org/10.1182/blood-2006-01-009803
61 https://doi.org/10.1182/blood-2006-12-063941
62 https://doi.org/10.1182/blood.v97.12.3846
63 https://doi.org/10.1182/blood.v99.6.2054
64 https://doi.org/10.3324/haematol.12020
65 https://doi.org/10.3324/haematol.12855
66 https://doi.org/10.7326/0003-4819-108-2-206
67 https://doi.org/10.7326/0003-4819-135-12-200112180-00008
68 https://doi.org/10.7326/0003-4819-139-3-200308050-00021-w4
69 https://doi.org/10.7326/0003-4819-143-10-200511150-00028
70 https://doi.org/10.7326/0003-4819-146-9-200705010-00009
71 https://doi.org/10.7326/0003-4819-60-3-506
72 schema:datePublished 2010
73 schema:datePublishedReg 2010-01-01
74 schema:description Numerous medications and other xenobiotics are capable of producing adverse reactions (ADRs) affecting red cells, platelets or neutrophils. Occasionally, more than one blood element is affected simultaneously. As with all drug reactions, some side effects are a direct consequence of a known pharmacologic action of the drug and are dose-dependent; others occur sporadically and relatively independent of dose. The latter ("idiosyncratic") reactions are unpredictable and, in general, have no known underlying genetic basis. Many are antibody-mediated, as would be expected since cellular immune effector cells have little direct access to circulating blood cells. In this chapter, we will discuss idiosyncratic drug reactions affecting blood and blood forming tissues with an emphasis on those thought to be immune-mediated.
75 schema:editor N2178b1b831a04f38817f671393f6df49
76 schema:genre chapter
77 schema:inLanguage en
78 schema:isAccessibleForFree false
79 schema:isPartOf Nf54c1cadc57541f3a638d319d6dc242a
80 schema:name Adverse Drug Reactions Affecting Blood Cells
81 schema:pagination 57-76
82 schema:productId N06eb709b71d94a8a9e3628798e3dd79e
83 N3cd59f6f15c043e6b12dfd7c3d01894f
84 N71a76e8f01af4c22aa32acbb854d5832
85 N9acf52323ad64d72adb87e122e95770f
86 schema:publisher Nbb5216a260c0411ea0ece88a81f2b046
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048690557
88 https://doi.org/10.1007/978-3-642-00663-0_3
89 schema:sdDatePublished 2019-04-15T17:16
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher Nfc43d5f139604695a331f0d2116d0e26
92 schema:url http://link.springer.com/10.1007/978-3-642-00663-0_3
93 sgo:license sg:explorer/license/
94 sgo:sdDataset chapters
95 rdf:type schema:Chapter
96 N06eb709b71d94a8a9e3628798e3dd79e schema:name dimensions_id
97 schema:value pub.1048690557
98 rdf:type schema:PropertyValue
99 N0e7c9e1d05b340bda97669416c41a5a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Neutrophils
101 rdf:type schema:DefinedTerm
102 N10fa9301b5d547adb4f93eaa300bf7d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Environmental Pollutants
104 rdf:type schema:DefinedTerm
105 N14ce2fb768c145c7b6bbcbbc71047777 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Drug-Related Side Effects and Adverse Reactions
107 rdf:type schema:DefinedTerm
108 N2178b1b831a04f38817f671393f6df49 rdf:first N801b10dcfc544d2b8a0f58afb732bb8b
109 rdf:rest rdf:nil
110 N2d0cb1421fec483088822216230c95df rdf:first sg:person.015510362157.72
111 rdf:rest rdf:nil
112 N3cd59f6f15c043e6b12dfd7c3d01894f schema:name readcube_id
113 schema:value e7f3fe2d22243ba9667c217b32ce8e07a5d74656238da9cf392f8985cf9f96f7
114 rdf:type schema:PropertyValue
115 N48bec2778ef14d0a9bc6b62c7957f2b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Blood Cells
117 rdf:type schema:DefinedTerm
118 N54a550b53af04c278916dbc705563e3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Erythrocytes
120 rdf:type schema:DefinedTerm
121 N62e3add3ad6c428dbff46b5b6d72b08a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Hematologic Diseases
123 rdf:type schema:DefinedTerm
124 N66f63e03343a4a9db20f15a5d104d91d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Animals
126 rdf:type schema:DefinedTerm
127 N6deaf61026ac4829a0d4750ec032477a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 N71a76e8f01af4c22aa32acbb854d5832 schema:name pubmed_id
131 schema:value 20020259
132 rdf:type schema:PropertyValue
133 N801b10dcfc544d2b8a0f58afb732bb8b schema:familyName Uetrecht
134 schema:givenName Jack
135 rdf:type schema:Person
136 N9acf52323ad64d72adb87e122e95770f schema:name doi
137 schema:value 10.1007/978-3-642-00663-0_3
138 rdf:type schema:PropertyValue
139 Nbb5216a260c0411ea0ece88a81f2b046 schema:location Berlin, Heidelberg
140 schema:name Springer Berlin Heidelberg
141 rdf:type schema:Organisation
142 Nbd8ce799d4a041c295161ee1e0186513 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Anemia, Aplastic
144 rdf:type schema:DefinedTerm
145 Nd099281cceed4551a1e551d0931011e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Blood Platelets
147 rdf:type schema:DefinedTerm
148 Nf54c1cadc57541f3a638d319d6dc242a schema:isbn 978-3-642-00662-3
149 978-3-642-00663-0
150 schema:name Adverse Drug Reactions
151 rdf:type schema:Book
152 Nfc43d5f139604695a331f0d2116d0e26 schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
155 schema:name Medical and Health Sciences
156 rdf:type schema:DefinedTerm
157 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
158 schema:name Immunology
159 rdf:type schema:DefinedTerm
160 sg:grant.2529602 http://pending.schema.org/fundedItem sg:pub.10.1007/978-3-642-00663-0_3
161 rdf:type schema:MonetaryGrant
162 sg:person.015510362157.72 schema:affiliation https://www.grid.ac/institutes/grid.280427.b
163 schema:familyName Aster
164 schema:givenName Richard H.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015510362157.72
166 rdf:type schema:Person
167 https://app.dimensions.ai/details/publication/pub.1075114469 schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1075853296 schema:CreativeWork
169 https://app.dimensions.ai/details/publication/pub.1076860435 schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1077609539 schema:CreativeWork
171 https://app.dimensions.ai/details/publication/pub.1077806545 schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1079456767 schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1079556962 schema:CreativeWork
174 https://app.dimensions.ai/details/publication/pub.1082343223 schema:CreativeWork
175 https://app.dimensions.ai/details/publication/pub.1083111457 schema:CreativeWork
176 https://doi.org/10.1001/archinte.164.2.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013420627
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1002/ajh.10331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008035352
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1002/ajh.20490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030458022
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1002/ajh.20516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021574335
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1002/pds.1542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041992880
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/0049-0172(87)90006-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032947584
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.ejim.2006.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026512583
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.hoc.2007.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027300792
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0037-1963(00)90101-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025052028
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0755-4982(04)98884-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000039512
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0887-7963(93)70142-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027647599
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s0887-7963(93)70144-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020385171
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/s0887-7963(93)70145-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053577207
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/s0953-6205(02)00085-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007034376
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1046/j.1537-2995.1984.24384225022.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041557497
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1046/j.1537-2995.1990.30891020326.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028355857
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1046/j.1537-2995.1994.341195065037.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037410831
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1046/j.1537-2995.2000.40060663.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014188860
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1053/j.seminhematol.2005.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005842429
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1054/mehy.1998.0734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040493147
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1055/s-2004-831039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057437129
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1056/nejm198508223130803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047681361
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1056/nejmra066469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039578506
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1073/pnas.0404201101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004832467
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1097/moh.0b013e3282f15fb9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028182276
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1097/moh.0b013e3282fa7470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007863510
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1111/j.1365-2141.1986.tb04130.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008686684
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1111/j.1365-2141.1991.tb08624.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024449102
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1111/j.1365-2141.1993.tb03070.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002889538
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1111/j.1526-0968.2003.00127.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048984191
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1111/j.1537-2995.2007.01173.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049944359
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/j.1538-7836.2004.00744.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027766803
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1124/mol.58.1.207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074656334
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1161/01.cir.97.17.1680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010066561
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1172/jci110710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004799896
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1172/jci111691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020217781
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1172/jci112901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016459002
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1182/blood-2006-01-009803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049008460
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1182/blood-2006-12-063941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033660809
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1182/blood.v97.12.3846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046021090
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1182/blood.v99.6.2054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013354856
257 rdf:type schema:CreativeWork
258 https://doi.org/10.3324/haematol.12020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005655843
259 rdf:type schema:CreativeWork
260 https://doi.org/10.3324/haematol.12855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016498048
261 rdf:type schema:CreativeWork
262 https://doi.org/10.7326/0003-4819-108-2-206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073692427
263 rdf:type schema:CreativeWork
264 https://doi.org/10.7326/0003-4819-135-12-200112180-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073704955
265 rdf:type schema:CreativeWork
266 https://doi.org/10.7326/0003-4819-139-3-200308050-00021-w4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073706468
267 rdf:type schema:CreativeWork
268 https://doi.org/10.7326/0003-4819-143-10-200511150-00028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073708178
269 rdf:type schema:CreativeWork
270 https://doi.org/10.7326/0003-4819-146-9-200705010-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073709281
271 rdf:type schema:CreativeWork
272 https://doi.org/10.7326/0003-4819-60-3-506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073722496
273 rdf:type schema:CreativeWork
274 https://www.grid.ac/institutes/grid.280427.b schema:alternateName Bloodcenter of Wisconsin
275 schema:name Blood Research Institute, Blood Center of Wisconsin, 2178 Watertown Plank Rd, Milwaukee, 53201, WI, USA
276 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...