Enhanced activity of immunoproteasomes in patiens with Crohn’s disease View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009

AUTHORS

A. Visekruna , H. J. Buhr , J. P. Ritz , N. Slavova , S. Dullat , A. J. Kroesen , U. Steinhoff

ABSTRACT

The eukaryotic 20S proteasome is the main protease in the cytoplasm and nucleus composed of seven different α and seven different β subunits which form four rings stacked on top of each other. It is now known that the constitutive proteasome is the predominant form in most tissue. Our current study demonstrates that the second form, inducible immunoproteasome is more abundant in inflamed ileum and colon of Crohn’s disease. Especially, immunosubunit β1 i is increasingly expressed in the inflamed intestinal tissue of patients with Crohn’s disease. We show here that this subunit exchange alters the cleavage pattern of proteasomes in the inflamed intestine of patients with Crohn’s disease contributing directly to the activation of NF-kB by increasing the processing of p105 and degradation of IkBα. Thus, the immunoproteasome is involved in the enhanced activity of NF.-kB which is one of the most important regulators of proinflammatory gene expression in intestinal inflammation. More... »

PAGES

233-234

References to SciGraph publications

Book

TITLE

Chirurgisches Forum und DGAV Forum 2009

ISBN

978-3-642-00624-1
978-3-642-00625-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-00625-8_86

DOI

http://dx.doi.org/10.1007/978-3-642-00625-8_86

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031356305


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