Staphylococcal Biofilms View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2008

AUTHORS

M. Otto

ABSTRACT

Staphylococcus epidermidis and Staphylococcus aureus are the most frequent causes of nosocomial infections and infections on indwelling medical devices, which characteristically involve biofilms. Recent advances in staphylococcal molecular biology have provided more detailed insight into the basis of biofilm formation in these opportunistic pathogens. A series of surface proteins mediate initial attachment to host matrix proteins, which is followed by the expression of a cationic glucosamine-based exopolysaccharide that aggregates the bacterial cells. In some cases, proteins may function as alternative aggregating substances. Furthermore, surfactant peptides have now been recognized as key factors involved in generating the three-dimensional structure of a staphylococcal biofilm by cellcell disruptive forces, which eventually may lead to the detachment of entire cell clusters. Transcriptional profiling experiments have defined the specific physiology of staphylococcal biofilms and demonstrated that biofilm resistance to antimicrobials is due to gene-regulated processes. Finally, novel animal models of staphylococcal biofilm-associated infection have given us important information on which factors define biofilm formation in vivo. These recent advances constitute an important basis for the development of anti-staphylococcal drugs and vaccines. More... »

PAGES

207-228

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-540-75418-3_10

DOI

http://dx.doi.org/10.1007/978-3-540-75418-3_10

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010961510

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18453278


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biofilms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Staphylococcal Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Staphylococcus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratory of Human Bacterial Pathogenesis, The National Institutes of Health, Hamilton, MT, USA", 
          "id": "http://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Laboratory of Human Bacterial Pathogenesis, The National Institutes of Health, Hamilton, MT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Otto", 
        "givenName": "M.", 
        "id": "sg:person.0753532737.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753532737.80"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2008", 
    "datePublishedReg": "2008-01-01", 
    "description": "Staphylococcus epidermidis and Staphylococcus aureus are the most frequent causes of nosocomial infections and infections on indwelling medical devices, which characteristically involve biofilms. Recent advances in staphylococcal molecular biology have provided more detailed insight into the basis of biofilm formation in these opportunistic pathogens. A series of surface proteins mediate initial attachment to host matrix proteins, which is followed by the expression of a cationic glucosamine-based exopolysaccharide that aggregates the bacterial cells. In some cases, proteins may function as alternative aggregating substances. Furthermore, surfactant peptides have now been recognized as key factors involved in generating the three-dimensional structure of a staphylococcal biofilm by cellcell disruptive forces, which eventually may lead to the detachment of entire cell clusters. Transcriptional profiling experiments have defined the specific physiology of staphylococcal biofilms and demonstrated that biofilm resistance to antimicrobials is due to gene-regulated processes. Finally, novel animal models of staphylococcal biofilm-associated infection have given us important information on which factors define biofilm formation in vivo. These recent advances constitute an important basis for the development of anti-staphylococcal drugs and vaccines.", 
    "editor": [
      {
        "familyName": "Romeo", 
        "givenName": "Tony", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-540-75418-3_10", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": {
      "isbn": [
        "978-3-540-75417-6", 
        "978-3-540-75418-3"
      ], 
      "name": "Bacterial Biofilms", 
      "type": "Book"
    }, 
    "keywords": [
      "gene-regulated processes", 
      "biofilm formation", 
      "transcriptional profiling experiments", 
      "host matrix proteins", 
      "three-dimensional structure", 
      "staphylococcal biofilms", 
      "matrix proteins", 
      "molecular biology", 
      "profiling experiments", 
      "bacterial cells", 
      "biofilm-associated infections", 
      "surface proteins", 
      "biofilm resistance", 
      "specific physiology", 
      "opportunistic pathogen", 
      "staphylococcal biofilm-associated infections", 
      "recent advances", 
      "protein", 
      "biofilms", 
      "surfactant peptides", 
      "cell clusters", 
      "initial attachment", 
      "detailed insight", 
      "novel animal model", 
      "biology", 
      "exopolysaccharide", 
      "physiology", 
      "pathogens", 
      "expression", 
      "cells", 
      "vivo", 
      "Staphylococcus epidermidis", 
      "important basis", 
      "animal models", 
      "peptides", 
      "formation", 
      "Staphylococcus aureus", 
      "important information", 
      "anti-staphylococcal drugs", 
      "advances", 
      "key factors", 
      "insights", 
      "infection", 
      "basis", 
      "factors", 
      "clusters", 
      "attachment", 
      "resistance", 
      "development", 
      "antimicrobials", 
      "disruptive forces", 
      "epidermidis", 
      "structure", 
      "aureus", 
      "process", 
      "experiments", 
      "substances", 
      "frequent cause", 
      "information", 
      "drugs", 
      "detachment", 
      "nosocomial infections", 
      "cause", 
      "vaccine", 
      "model", 
      "series", 
      "force", 
      "medical devices", 
      "cases", 
      "devices"
    ], 
    "name": "Staphylococcal Biofilms", 
    "pagination": "207-228", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010961510"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-540-75418-3_10"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18453278"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-540-75418-3_10", 
      "https://app.dimensions.ai/details/publication/pub.1010961510"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-06-01T22:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/chapter/chapter_126.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-3-540-75418-3_10"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-540-75418-3_10'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-540-75418-3_10'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-540-75418-3_10'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-540-75418-3_10'


 

This table displays all metadata directly associated to this object as RDF triples.

154 TRIPLES      23 PREDICATES      102 URIs      94 LITERALS      12 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-540-75418-3_10 schema:about N1a6004d6fae8471d8a296311819dd1eb
2 N2efd5a4ebf85460986888aec6fb4d7b4
3 N70d24b1ee1a340dfba3e98694fccc96d
4 Nb57b4d9b254f4b96947c737e906c5e51
5 anzsrc-for:06
6 anzsrc-for:0601
7 anzsrc-for:0605
8 schema:author N0f5838ea3f4a4cec97f34ce0a726f70b
9 schema:datePublished 2008
10 schema:datePublishedReg 2008-01-01
11 schema:description Staphylococcus epidermidis and Staphylococcus aureus are the most frequent causes of nosocomial infections and infections on indwelling medical devices, which characteristically involve biofilms. Recent advances in staphylococcal molecular biology have provided more detailed insight into the basis of biofilm formation in these opportunistic pathogens. A series of surface proteins mediate initial attachment to host matrix proteins, which is followed by the expression of a cationic glucosamine-based exopolysaccharide that aggregates the bacterial cells. In some cases, proteins may function as alternative aggregating substances. Furthermore, surfactant peptides have now been recognized as key factors involved in generating the three-dimensional structure of a staphylococcal biofilm by cellcell disruptive forces, which eventually may lead to the detachment of entire cell clusters. Transcriptional profiling experiments have defined the specific physiology of staphylococcal biofilms and demonstrated that biofilm resistance to antimicrobials is due to gene-regulated processes. Finally, novel animal models of staphylococcal biofilm-associated infection have given us important information on which factors define biofilm formation in vivo. These recent advances constitute an important basis for the development of anti-staphylococcal drugs and vaccines.
12 schema:editor Ne13d40b440d3426dab11c425b368a814
13 schema:genre chapter
14 schema:inLanguage en
15 schema:isAccessibleForFree true
16 schema:isPartOf Nc02d13592273497b8555d17cb0d62c0d
17 schema:keywords Staphylococcus aureus
18 Staphylococcus epidermidis
19 advances
20 animal models
21 anti-staphylococcal drugs
22 antimicrobials
23 attachment
24 aureus
25 bacterial cells
26 basis
27 biofilm formation
28 biofilm resistance
29 biofilm-associated infections
30 biofilms
31 biology
32 cases
33 cause
34 cell clusters
35 cells
36 clusters
37 detachment
38 detailed insight
39 development
40 devices
41 disruptive forces
42 drugs
43 epidermidis
44 exopolysaccharide
45 experiments
46 expression
47 factors
48 force
49 formation
50 frequent cause
51 gene-regulated processes
52 host matrix proteins
53 important basis
54 important information
55 infection
56 information
57 initial attachment
58 insights
59 key factors
60 matrix proteins
61 medical devices
62 model
63 molecular biology
64 nosocomial infections
65 novel animal model
66 opportunistic pathogen
67 pathogens
68 peptides
69 physiology
70 process
71 profiling experiments
72 protein
73 recent advances
74 resistance
75 series
76 specific physiology
77 staphylococcal biofilm-associated infections
78 staphylococcal biofilms
79 structure
80 substances
81 surface proteins
82 surfactant peptides
83 three-dimensional structure
84 transcriptional profiling experiments
85 vaccine
86 vivo
87 schema:name Staphylococcal Biofilms
88 schema:pagination 207-228
89 schema:productId N17ee0e5338924c84b228d040a7ae0ebd
90 N3b95a9933a0643b885a3a6c0c1b64e01
91 N4af42e373ba6471cae3a07ce48871aff
92 schema:publisher N0fff8538e0854e7baa39c0eac46e9c76
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010961510
94 https://doi.org/10.1007/978-3-540-75418-3_10
95 schema:sdDatePublished 2022-06-01T22:27
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N64afbc353f2d4f9a866524fa0da93607
98 schema:url https://doi.org/10.1007/978-3-540-75418-3_10
99 sgo:license sg:explorer/license/
100 sgo:sdDataset chapters
101 rdf:type schema:Chapter
102 N0f5838ea3f4a4cec97f34ce0a726f70b rdf:first sg:person.0753532737.80
103 rdf:rest rdf:nil
104 N0fff8538e0854e7baa39c0eac46e9c76 schema:name Springer Nature
105 rdf:type schema:Organisation
106 N17ee0e5338924c84b228d040a7ae0ebd schema:name pubmed_id
107 schema:value 18453278
108 rdf:type schema:PropertyValue
109 N1a6004d6fae8471d8a296311819dd1eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Humans
111 rdf:type schema:DefinedTerm
112 N2efd5a4ebf85460986888aec6fb4d7b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Staphylococcus
114 rdf:type schema:DefinedTerm
115 N3b95a9933a0643b885a3a6c0c1b64e01 schema:name doi
116 schema:value 10.1007/978-3-540-75418-3_10
117 rdf:type schema:PropertyValue
118 N4af42e373ba6471cae3a07ce48871aff schema:name dimensions_id
119 schema:value pub.1010961510
120 rdf:type schema:PropertyValue
121 N64afbc353f2d4f9a866524fa0da93607 schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 N70d24b1ee1a340dfba3e98694fccc96d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Biofilms
125 rdf:type schema:DefinedTerm
126 Nb57b4d9b254f4b96947c737e906c5e51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Staphylococcal Infections
128 rdf:type schema:DefinedTerm
129 Nc02d13592273497b8555d17cb0d62c0d schema:isbn 978-3-540-75417-6
130 978-3-540-75418-3
131 schema:name Bacterial Biofilms
132 rdf:type schema:Book
133 Nd7ded88f936e43389a71f4b02163c617 schema:familyName Romeo
134 schema:givenName Tony
135 rdf:type schema:Person
136 Ne13d40b440d3426dab11c425b368a814 rdf:first Nd7ded88f936e43389a71f4b02163c617
137 rdf:rest rdf:nil
138 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
139 schema:name Biological Sciences
140 rdf:type schema:DefinedTerm
141 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
142 schema:name Biochemistry and Cell Biology
143 rdf:type schema:DefinedTerm
144 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
145 schema:name Microbiology
146 rdf:type schema:DefinedTerm
147 sg:person.0753532737.80 schema:affiliation grid-institutes:grid.94365.3d
148 schema:familyName Otto
149 schema:givenName M.
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753532737.80
151 rdf:type schema:Person
152 grid-institutes:grid.94365.3d schema:alternateName Laboratory of Human Bacterial Pathogenesis, The National Institutes of Health, Hamilton, MT, USA
153 schema:name Laboratory of Human Bacterial Pathogenesis, The National Institutes of Health, Hamilton, MT, USA
154 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...