Bringing Folding Pathways into Strand Pairing Prediction View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

Jieun K. Jeong , Piotr Berman , Teresa M. Przytycka

ABSTRACT

The topology of β-sheets is defined by the pattern of hydrogen-bonded strand pairing. Therefore, predicting hydrogen bonded strand partners is a fundamental step towards predicting β-sheet topology. In this work we report a new strand pairing algorithm. Our algorithm attempts to mimic elements of the folding process. Namely, in addition to ensuring that the predicted hydrogen bonded strand pairs satisfy basic global consistency constraints, it takes into account hypothetical folding pathways. Consistently with this view, introducing hydrogen bonds between a pair of strands changes the probabilities of forming other strand pairs. We demonstrate that this approach provides an improvement over previously proposed algorithms. More... »

PAGES

38-48

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-540-74126-8_5

DOI

http://dx.doi.org/10.1007/978-3-540-74126-8_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039414859


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