Mycobacterium avium subspecies paratuberculosis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009

AUTHORS

Ling-Ling Li , Sushmita Singh , John Bannantine , Sagarika Kanjilal , Vivek Kapur

ABSTRACT

Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne’s disease in cattle and other domesticated and wild ruminant species. The organism and disease were first described over a century ago, and despite the considerable morbidity and mortality associated with Map infection in animal agriculture, relatively little is known about the molecular mechanisms of virulence and pathogenesis of infection or the population structure and molecular epidemiology of the bacterium. The description of the complete genome sequence of the K-10 strain of Map in 2005 has catalyzed and enabled research in these areas, particularly as relates to methods for strain differentiation and diagnostic test development. In the current chapter, we provide a post-genomics perspective on our current understanding of the bacterium and the disease it causes, and highlight our current understanding of the population structure of Map. Overall, the availability of the genome sequence of Map has provided a strong foundation for the rational development of the next generation of tools and techniques for the prevention and control of this devastating animal pathogen. More... »

PAGES

65-83

Book

TITLE

Genome Mapping and Genomics in Animal-Associated Microbes

ISBN

978-3-540-74040-7
978-3-540-74042-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-540-74042-1_2

DOI

http://dx.doi.org/10.1007/978-3-540-74042-1_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044995456


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