Septische Lungenfunktionsstörungen können durch eine enterale Immunonutrition mit Olivenöl positiv beeinflusst werden View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

Jörg Glatzle , S. Beckert , M. S. Kasparek , M. H. Müller , T. Meile , A. Königsrainer , W. Steurer

ABSTRACT

Via the thoracic duct, the lung is the first organ exposed to gut derived mediators released into mesenteric lymph. Inflammatory mediators are released during sepsis into mesenteric lymph inducing pulmonary dysfunction Aim: To investigate whether an enteral immunonutrition with olive oil prevents septic pulmonary dysfunctions. Methods: Mesenteric lymph was obtained from lymph fistula donor rats during sepsis (LPS 5 mg/kg i. p.) with and without enteral immunonutrition with olive oil. Sepsis lymph was then reinfused into the jugular vein of separate recipient rats. Thereafter, the lung tissue was analyzed for distance of oxygen diffusion, inflammatory response and cell apoptosis. Results: Sepsis increased TNFα release into mesenteric lymph about 100fold, whereas an enteral immunonutrition reduced the TNFα release by more than 5fold. Sepsis lymph induced a significant increase in alveolar wall thickness, inflammatory reaction and apoptosis, whereas sepsis lymph collected during an enteral immunonutrition with olive oil induced only a mild inflammation but no apoptosis in the lung of recipient rats. Conclusions: Mediators in sepsis lymph induce pulmonary dysfunction. The lung may be protected by an enteral immunonutrition containing long chain fatty acids. More... »

PAGES

1-3

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http://scigraph.springernature.com/pub.10.1007/978-3-540-71123-0_1

DOI

http://dx.doi.org/10.1007/978-3-540-71123-0_1

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