IFN-alpha in the Generation of Dendritic Cells for Cancer Immunotherapy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009

AUTHORS

Stefano Maria Santini , Caterina Lapenta , Laura Santodonato , Giuseppina D'Agostino , Filippo Belardelli , Maria Ferrantini

ABSTRACT

Dendritic cells (DCs) play a crucial role in linking innate and adaptive immunity, by virtue of their unique ability to take up and process antigens in the peripheral blood and tissues and, upon migration to draining lymph nodes, to present antigen to resting lymphocytes. Notably, these DC functions are modulated by cytokines and chemokines controlling the activation and maturation of these cells, thus shaping the response towards either immunity or tolerance.An ensemble of recent studies have emphasized an important role of type I IFNs in the DC differentiation/activation, suggesting the existence of a natural alliance between these cytokines and DCs in linking innate and adaptive immunity. Herein, we will review how type I IFNs can promote the ex vivo differentiation of human DCs and orient DC functions towards the priming and expansion of protective antitumor immune responses. We will also discuss how the knowledge on type I IFN-DC interactions could be exploited for the design of more selective and effective strategies of cancer immunotherapy. More... »

PAGES

295-317

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-540-71029-5_14

DOI

http://dx.doi.org/10.1007/978-3-540-71029-5_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005854884

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19031032


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