Translational Control by RNA-RNA Interaction: Improved Computation of RNA-RNA Binding Thermodynamics View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2008

AUTHORS

Ulrike Mückstein , Hakim Tafer , Stephan H. Bernhart , Maribel Hernandez-Rosales , Jörg Vogel , Peter F. Stadler , Ivo L. Hofacker

ABSTRACT

The thermodynamics of RNA-RNA interaction consists of two components: the energy necessary to make a potential binding region accessible, i.e. unpaired, and the energy gained from the base pairing of the two interaction partners. We show here that both components can be efficiently computed using an improved variant of RNAup. The method is then applied to a set of bacterial small RNAs involved in translational control. In all cases of biologically active sRNA target interactions, the target sites predicted by RNAup are in perfect agreement with literature. In addition to prediction of target site location, RNAup can also be used to determine the mode of sRNA action. Using information about target site location and the accessibility change resulting from sRNA binding we can discriminate between positive and negative regulators of translation. More... »

PAGES

114-127

References to SciGraph publications

Book

TITLE

Bioinformatics Research and Development

ISBN

978-3-540-70598-7
978-3-540-70600-7

From Grant

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-540-70600-7_9

DOI

http://dx.doi.org/10.1007/978-3-540-70600-7_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002627539


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