Molekülmodelle und Modellmoleküle: Strukturanalyse großer biologischer Moleküle für die Medizin View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008

AUTHORS

Yves A. Muller , Udo Heinemann

ABSTRACT

Die Molekulare Medizin handelt von Molekülen und ihren vielfältigen Funktionen im gesunden und kranken Organismus. Diese Funktionen sind eng an die genaue dreidimensionale Molekülstruktur geknüpft: Die große Mehrzahl der Proteine und Nukleinsäuren einer Zelle besitzen eine definierte räumliche Struktur, die auf der Ebene einzelner Atome exakt beschrieben werden kann. Ein wichtiger Teil dieser Struktur sind charakteristisch geformte Oberflächen mit diskreten biophysikalischen Eigenschaften wie elektrostatisches Potenzial, Hydrophobizität oder die Fähigkeit zur Ausbildung gerichteter, nichtkovalenter Wechselwirkungen (z. B. durch Wasserstoffbrücken) mit anderen Molekülen. Die Komplementarität dieser Oberflächen ist für die Interaktion zwischen Molekülen und damit die Ausprägung ihrer Funktionalität entscheidend. More... »

PAGES

275-294

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  • Book

    TITLE

    Grundlagen der Molekularen Medizin

    ISBN

    978-3-540-69412-0
    978-3-540-69414-4

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-540-69414-4_11

    DOI

    http://dx.doi.org/10.1007/978-3-540-69414-4_11

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018426233


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