Anaplastic Thyroid Carcinoma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007-01-01

AUTHORS

Christian Passler , Reza Asari , Christian Scheuba , Bruno Niederle

ABSTRACT

12.13 ConclusionMultimodal treatment using hyperfractionated radiotherapy, chemotherapy, and surgery may be the treatment of choice for ATC. Surgery plays an important role because local tumor control cannot be achieved without debulking of large tumor masses.Current evidence indicates that undifferentiated thyroid carcinoma originates from follicular cells. Therefore prognostic factors are related primarily to the extent of the disease at presentation. A small number of patients with completely resectable tumors (mainly as incidental ATC in the form of small foci of ATC in differentiated carcinomas) may be cured by aggressive surgery in combination with radiotherapy and chemotherapy. Nevertheless, in most patients death from ATC cannot be avoided, since multimodal treatment does not have much influence on distant metastases and thus on the survival rate. However, quality of life can be improved. It is probably less severe to die from distant metastases, than from suffocation due to failure of local tumor control. Although future therapeutic aspects are promising, clinical trials showing their impact on survival are still lacking. More... »

PAGES

161-170

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-540-68043-7_12

DOI

http://dx.doi.org/10.1007/978-3-540-68043-7_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031098539


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