Poly (lactic-co-glycolic acid) and hydroxyapatite composite films for cartilage reconstruction View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

J. B. Lee , C. W. Mun , H. H. Choi , J. C. Park , J. B. Choi , Jeong Koo Kim

ABSTRACT

PLGA (75:25)/hydroxyapatite (HA) composite films were fabricated by solvent-casting method to investigate the effect of various hydroxyapatite content ratio to the PLGA for mechanical properties, cellular attachment and proliferation. Mechanical property of the composite film was characterized by tensile test. The ultimate tensile strength of 10 wt% HA content film was two-fold higher than control group. Surface of the film was characterized by contact angle measurement and scanning electron microscope (SEM). The PLGA/HA composites were more hydrophilic than control. Chondrocyte responses to the composite films were measured in vitro by cellular attachment and proliferation test. The attached and proliferated cells were significantly higher on PLGA/HA (10 wt%) composite film than control group (1.44 times higher in attachment test and 1.31 times higher for 6th-day at culture in proliferation assaying, p<0.05). More... »

PAGES

130-133

References to SciGraph publications

  • 1997-06. Preparation and mechanical properties of calcium phosphate/copoly-L-lactide composites in JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE
  • Book

    TITLE

    3rd Kuala Lumpur International Conference on Biomedical Engineering 2006

    ISBN

    978-3-540-68016-1
    978-3-540-68017-8

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-540-68017-8_33

    DOI

    http://dx.doi.org/10.1007/978-3-540-68017-8_33

    DIMENSIONS

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