Prevention and Treatment of Radiation Injuries View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2008

AUTHORS

Eric P. Cohen , Melissa M. Joines , John E. Moulder

ABSTRACT

The renin-angiotensin system, local or systemic, plays a key role in normal tissue radiation injury. Angiotensin converting enzyme (ACE) inhibitors, which act to attenuate the conversion of angiotensin I to angiotensin II, are beneficial in mitigating experimental renal, lung, or brain normal tissue radiation injury. The benefit of ACE inhibitors and angiotensin II blockers has been particularly well documented in experimental radiation nephropathy, for either mitigation or treatment. The mechanism for this benefit remains incompletely understood. In particular, control of hypertension, proteinuria, or radiation-induced cell proliferation alone does not appear to determine the benefit of ACE inhibitors or angiotensin II blockers. Nonetheless, the significant experimental benefit of those agents fully justifies their use in human radiation nephropathy. Clinical trials using ACE inhibitors are underway in subjects undergoing radiation-based bone marrow transplantation and also in subjects undergoing curative radiotherapy for lung cancer. More... »

PAGES

69-76

References to SciGraph publications

Book

TITLE

Late Effects of Cancer Treatment on Normal Tissues

ISBN

978-3-540-49069-2
978-3-540-49070-8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-540-49070-8_9

DOI

http://dx.doi.org/10.1007/978-3-540-49070-8_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027238826


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