Natural History of Prostatic Carcinoma: The Pathologist’s Perspective View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2007

AUTHORS

Ferran Algaba , Isabel Trias , Yolanda Arce

ABSTRACT

The stem (basal) cells of prostate acini are considered the origin of prostate cancer. Between these cells and the final secretory cells, different intermediate or transit cells can be observed, and every one of them can evolve into malignant cells, explaining the biological variability of prostatic cancer. The exact changes between normal gland and prostatic intraepithelial neoplasia (PIN) are not yet known, but a post-inflammatory atrophy lesion is being studied in this respect. The PIN lesion is considered the pre-invasive change of prostatic cancer and its presence in needle biopsy is clinically used for follow-up of the patient. The progressive knowledge of the stromal invasion in prostate cancer (loss of some cell-cell adhesion molecules and expression of others) can be correlated with the Gleason grading system, and the molecular changes in the progression to androgen-independent carcinoma can be used as a prognostic marker in conjunction with the classical pathological markers. More... »

PAGES

9-24

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-540-40901-4_2

DOI

http://dx.doi.org/10.1007/978-3-540-40901-4_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010671748

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17432551


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