The dual-specific protein tyrosine phosphatase family View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2004

AUTHORS

Andres Alonso , Ana Rojas , Adam Godzik , Tomas Mustelin

ABSTRACT

Dual-specificity protein phosphatases (DSPs) belong to the protein tyrosine phosphatase (PTP) superfamily since they contain the conserved motif HCX2GX2R and share the same tertiary structure. The DSP family constitutes approximately half of all PTPs and includes a diverse group of proteins with a wide distribution among living organisms. They dephosphorylate proteins with phosphate on serine, threonine and/or tyrosine. The best-characterized substrates are the mitogenactivated protein kinases, which are dephosphorylated at tyrosine and threonine in a TXY motif. Additional substrates have been identified recently, ADF/cofilin for the slingshot DSP and glucokinase for DUSP12. DSPs can play key roles in multicellular organisms, as shown for the DSPs puckered and slingshot in the fruit fly and for LIP-1 in the worm. However, the physiological roles that DSPs play in higher vertebrates are largely unknown and there seems to be more redundancy. This chapter will discuss the evolution, structure, and function of the DSP family. More... »

PAGES

333-358

Book

TITLE

Protein Phosphatases

ISBN

978-3-540-20560-9
978-3-540-40035-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-540-40035-6_16

DOI

http://dx.doi.org/10.1007/978-3-540-40035-6_16

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017012386


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "Program of Signal Transduction, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alonso", 
        "givenName": "Andres", 
        "id": "sg:person.0716235410.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716235410.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "Program of Bioinformatics, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rojas", 
        "givenName": "Ana", 
        "id": "sg:person.0645005363.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645005363.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "Program of Bioinformatics, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Godzik", 
        "givenName": "Adam", 
        "id": "sg:person.01064406065.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064406065.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "Program of Signal Transduction, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mustelin", 
        "givenName": "Tomas", 
        "id": "sg:person.0650122210.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650122210.21"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2004", 
    "datePublishedReg": "2004-01-01", 
    "description": "Dual-specificity protein phosphatases (DSPs) belong to the protein tyrosine phosphatase (PTP) superfamily since they contain the conserved motif HCX2GX2R and share the same tertiary structure. The DSP family constitutes approximately half of all PTPs and includes a diverse group of proteins with a wide distribution among living organisms. They dephosphorylate proteins with phosphate on serine, threonine and/or tyrosine. The best-characterized substrates are the mitogenactivated protein kinases, which are dephosphorylated at tyrosine and threonine in a TXY motif. Additional substrates have been identified recently, ADF/cofilin for the slingshot DSP and glucokinase for DUSP12. DSPs can play key roles in multicellular organisms, as shown for the DSPs puckered and slingshot in the fruit fly and for LIP-1 in the worm. However, the physiological roles that DSPs play in higher vertebrates are largely unknown and there seems to be more redundancy. This chapter will discuss the evolution, structure, and function of the DSP family.", 
    "editor": [
      {
        "familyName": "Ari\u00f1o", 
        "givenName": "Joaqu\u00ed n", 
        "type": "Person"
      }, 
      {
        "familyName": "Alexander", 
        "givenName": "Denis R.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-540-40035-6_16", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": {
      "isbn": [
        "978-3-540-20560-9", 
        "978-3-540-40035-6"
      ], 
      "name": "Protein Phosphatases", 
      "type": "Book"
    }, 
    "name": "The dual-specific protein tyrosine phosphatase family", 
    "pagination": "333-358", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-540-40035-6_16"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "510e121d854ea916a1cc6539e743d643a827f9cbbc9a768c95239b46fe386912"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017012386"
        ]
      }
    ], 
    "publisher": {
      "location": "Berlin, Heidelberg", 
      "name": "Springer Berlin Heidelberg", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-540-40035-6_16", 
      "https://app.dimensions.ai/details/publication/pub.1017012386"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T20:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000029.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-3-540-40035-6_16"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-540-40035-6_16'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-540-40035-6_16'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-540-40035-6_16'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-540-40035-6_16'


 

This table displays all metadata directly associated to this object as RDF triples.

92 TRIPLES      22 PREDICATES      27 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-540-40035-6_16 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N853a1ff15851498381991ec4cd9cd81d
4 schema:datePublished 2004
5 schema:datePublishedReg 2004-01-01
6 schema:description Dual-specificity protein phosphatases (DSPs) belong to the protein tyrosine phosphatase (PTP) superfamily since they contain the conserved motif HCX2GX2R and share the same tertiary structure. The DSP family constitutes approximately half of all PTPs and includes a diverse group of proteins with a wide distribution among living organisms. They dephosphorylate proteins with phosphate on serine, threonine and/or tyrosine. The best-characterized substrates are the mitogenactivated protein kinases, which are dephosphorylated at tyrosine and threonine in a TXY motif. Additional substrates have been identified recently, ADF/cofilin for the slingshot DSP and glucokinase for DUSP12. DSPs can play key roles in multicellular organisms, as shown for the DSPs puckered and slingshot in the fruit fly and for LIP-1 in the worm. However, the physiological roles that DSPs play in higher vertebrates are largely unknown and there seems to be more redundancy. This chapter will discuss the evolution, structure, and function of the DSP family.
7 schema:editor Nc2e535f31e5d4d7eb72ae3aaff662ace
8 schema:genre chapter
9 schema:inLanguage en
10 schema:isAccessibleForFree true
11 schema:isPartOf Nf994a35ff88f4813807b86b5281accfe
12 schema:name The dual-specific protein tyrosine phosphatase family
13 schema:pagination 333-358
14 schema:productId N4315bde0ae5c4a3b826cea60af1406c7
15 N486efdc0bc1540478872d79892c96f2d
16 Nb6681884ec9e438689633dfe122b8a6a
17 schema:publisher N51b4fd5442cd4f01a36d0ae6872254da
18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017012386
19 https://doi.org/10.1007/978-3-540-40035-6_16
20 schema:sdDatePublished 2019-04-15T20:48
21 schema:sdLicense https://scigraph.springernature.com/explorer/license/
22 schema:sdPublisher Ne60e44cc91ea4413a2b6d2edfe0e418e
23 schema:url http://link.springer.com/10.1007/978-3-540-40035-6_16
24 sgo:license sg:explorer/license/
25 sgo:sdDataset chapters
26 rdf:type schema:Chapter
27 N4315bde0ae5c4a3b826cea60af1406c7 schema:name doi
28 schema:value 10.1007/978-3-540-40035-6_16
29 rdf:type schema:PropertyValue
30 N486efdc0bc1540478872d79892c96f2d schema:name readcube_id
31 schema:value 510e121d854ea916a1cc6539e743d643a827f9cbbc9a768c95239b46fe386912
32 rdf:type schema:PropertyValue
33 N51b4fd5442cd4f01a36d0ae6872254da schema:location Berlin, Heidelberg
34 schema:name Springer Berlin Heidelberg
35 rdf:type schema:Organisation
36 N5c79c7734c184805921fa5bb8a48feac schema:familyName Alexander
37 schema:givenName Denis R.
38 rdf:type schema:Person
39 N6c77ef672e604789ac97f5d79c7fdbb6 rdf:first sg:person.01064406065.43
40 rdf:rest Nafaa82eb3d0d4260a48e3d97135f7eb4
41 N853a1ff15851498381991ec4cd9cd81d rdf:first sg:person.0716235410.20
42 rdf:rest Nedcb9e72eea340c180006f3a2f7bcd3f
43 Nafaa82eb3d0d4260a48e3d97135f7eb4 rdf:first sg:person.0650122210.21
44 rdf:rest rdf:nil
45 Nb6681884ec9e438689633dfe122b8a6a schema:name dimensions_id
46 schema:value pub.1017012386
47 rdf:type schema:PropertyValue
48 Nbed1f4135835466da6c71d83aa003ceb rdf:first N5c79c7734c184805921fa5bb8a48feac
49 rdf:rest rdf:nil
50 Nc2e535f31e5d4d7eb72ae3aaff662ace rdf:first Nd629db18dda947fea899fd5c75144236
51 rdf:rest Nbed1f4135835466da6c71d83aa003ceb
52 Nd629db18dda947fea899fd5c75144236 schema:familyName Ariño
53 schema:givenName Joaquí n
54 rdf:type schema:Person
55 Ne60e44cc91ea4413a2b6d2edfe0e418e schema:name Springer Nature - SN SciGraph project
56 rdf:type schema:Organization
57 Nedcb9e72eea340c180006f3a2f7bcd3f rdf:first sg:person.0645005363.66
58 rdf:rest N6c77ef672e604789ac97f5d79c7fdbb6
59 Nf994a35ff88f4813807b86b5281accfe schema:isbn 978-3-540-20560-9
60 978-3-540-40035-6
61 schema:name Protein Phosphatases
62 rdf:type schema:Book
63 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
64 schema:name Biological Sciences
65 rdf:type schema:DefinedTerm
66 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
67 schema:name Biochemistry and Cell Biology
68 rdf:type schema:DefinedTerm
69 sg:person.01064406065.43 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
70 schema:familyName Godzik
71 schema:givenName Adam
72 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064406065.43
73 rdf:type schema:Person
74 sg:person.0645005363.66 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
75 schema:familyName Rojas
76 schema:givenName Ana
77 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645005363.66
78 rdf:type schema:Person
79 sg:person.0650122210.21 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
80 schema:familyName Mustelin
81 schema:givenName Tomas
82 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650122210.21
83 rdf:type schema:Person
84 sg:person.0716235410.20 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
85 schema:familyName Alonso
86 schema:givenName Andres
87 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716235410.20
88 rdf:type schema:Person
89 https://www.grid.ac/institutes/grid.479509.6 schema:alternateName Sanford Burnham Prebys Medical Discovery Institute
90 schema:name Program of Bioinformatics, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
91 Program of Signal Transduction, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
92 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...